《Reduced amino acid Schiff base containing ruthenium(III) complexes: Synthesis, characterization, DNA interaction, and in vitro cytotoxicity》 was published in Journal of Biochemical and Molecular Toxicology in 2020. These research results belong to Zhang, Zhaokuo; Yang, Ziwei; Wu, Yujing; Yuan, Zhen; Du, Jianlong; Li, Lijun. HPLC of Formula: 7524-52-9 The article mentions the following:
A number of reduced amino Schiff base ligands and corresponding ruthenium(III) complexes were designed and prepared based on the fact that amino acids not only possess multiple coordinate atoms but also improve the solubility of drugs in the body. The interaction of the complexes with calf thymus DNA was analyzed with spectroscopic methods of UV-visible absorption spectra, DNA competitive binding with ethidium bromide, CD spectra, and DNA melting experiments, and DNA viscosity measurements, indicating that the complexes bind to DNA primarily in the grooving mode. With respect to the ligands, the cytotoxicity in vitro of the complexes against Hela, A549, and MCF-7 cells was much enhanced, with most of the IC50 values less than 50μM or even comparable with those of cisplatin. After reading the article, we found that the author used H-Trp-OMe.HCl(cas: 7524-52-9HPLC of Formula: 7524-52-9)
H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.HPLC of Formula: 7524-52-9
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