Wang, Nan; Huang, Renxuan; Yang, Kunmeng; He, Yichun; Gao, Yufei; Dong, Delu published the artcile< Interfering with mitochondrial dynamics sensitizes glioblastoma multiforme to temozolomide chemotherapy>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is glioblastoma multiforme mitochondria oxidative phosphorylation temozolomide chemotherapy; AMPK; TP53; glioblastoma multiforme; mitochondrial dynamics; temozolomide.
Glioblastoma multiforme (GBM) is a primary tumor of the central nervous system (CNS) that exhibits the highest degree of malignancy. Radiotherapy and chemotherapy are essential to prolong the survival time of patients. However, clin. work has demonstrated that sensitivity of GBM to chemotherapy decreases with time. The phenomenon of multi-drug resistance (MDR) reminds us that there may exist some fundamental mechanisms in the process of chemo-resistance. We tried to explore the mechanism of GBM chemo-resistance from the perspective of energy metabolism First, we found that the oxidative phosphorylation (OXPHOS) level of SHG44 and U87 cells increased under TMZ treatment. In further studies, it was found that the expression of PINK1 and mitophagy flux downstream was downregulated in GBM cells, which were secondary to the upregulation of TP53 in tumor cells under TMZ treatment. At the same time, we examined the mitochondrial morphol. in tumor cells and found that the size of mitochondria in tumor cells increased under the treatment of TMZ, which originated from the regulation of AMPK on the subcellular localization of Drp1 under the condition of unbalanced energy supply and demand in tumor cells. The accumulation of mitochondrial mass and the optimization of mitochondrial quality accounted for the increased oxidative phosphorylation, and interruption of the mitochondrial fusion process downregulated the efficiency of oxidative phosphorylation and sensitized GBM cells to TMZ, which was also confirmed in the in vivo experiment What is more, interfering with this process is an innovative strategy to overcome the chemo-resistance of GBM cells.
Journal of Cellular and Molecular Medicine published new progress about Apoptosis-regulating proteins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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