Topczewski, Joseph J.; Kuder, Craig H.; Neighbors, Jeffrey D.; Hohl, Raymond J.; Wiemer, David F. published the artcile< Fluorescent schweinfurthin B and F analogs with anti-proliferative activity>, HPLC of Formula: 112-63-0, the main research area is schweinfurthin fluorescent analog synthesis antiproliferative anticancer cytotoxicity.
The natural tetracyclic schweinfurthins are potent and selective inhibitors of cell growth in the National Cancer Institute’s 60 cell-line screen. At this time, the mechanism or cellular target that underlies this activity has not yet been identified, and efforts to illuminate the schweinfurthins’ mode of action would benefit from development of potent fluorescent analogs that could be readily visualized within cells. This report described the synthesis of fluorescent analogs, such as I [R = H, R1 = OH, R2 = NO2; R = H, R1 = OMe, R2 = NO2, NH2; R = OH, R1 = OMe, R2 = NO2, NH2], of schweinfurthins B and F, and demonstrated that these compounds retain the potent and differentially toxic activities against select human cancer cells that are characteristic of the natural schweinfurthins. In addition, the synthesis of control compounds that maintain parallel fluorescent properties, but lack the potent activity of the natural schweinfurthin was described. Use of fluorescence microscopy showed differences between the localization of the active and relatively inactive schweinfurthin analogs. The active compounds localized in peripheral puncta which may identify the site(s) of activity.
Bioorganic & Medicinal Chemistry published new progress about Antiproliferative agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics