Thomson, Jennifer E.; Campbell, Craig D.; Concellon, Carmen; Duguet, Nicolas; Rix, Kathryn; Slawin, Alexandra M. Z.; Smith, Andrew D. published the artcile< Probing the Efficiency of N-Heterocyclic Carbene Promoted O- to C-Carboxyl Transfer of Oxazolyl Carbonates>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is carbonate oxazolyl Steglich rearrangement carboxyl transfer azolium salt catalyst; oxazolone alkoxycarbonyl aryloxycarbonyl preparation.
Screening a range of azolium salts, bases and solvents for reactivity indicates that triazolinylidenes, generated in situ with KHMDS in THF, promote the Steglich rearrangement of oxazolyl carbonates I (R1 = 4-MeOC6H4; R2 = Me, Me2CH, Me2CHCH2, MeSCH2CH2, Ph, PhCH2; R3 = Me, Me2CH, Cl3CCMe2, Ph, PhCH2, PhCH2CHMe, Me2CHCHMe) to [alkoxy(or aryloxy)carbonyl]oxazolones II with high catalytic efficiency (typical reaction time 5 min at <1.5 mol % NHC). This protocol shows wide substrate applicability, even allowing the efficient generation of vicinal quaternary centers. An improved exptl. procedure is also described that allows a simplified one-pot reaction protocol to be employed with similarly high catalytic efficiency. Journal of Organic Chemistry published new progress about Carbenes (methylene derivatives) Role: CAT (Catalyst Use), SPN (Synthetic Preparation), USES (Uses), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics