Sen, Arko; Prager, Briana C.; Zhong, Cuiqing; Park, Donglim; Zhu, Zhe; Gimple, Ryan C.; Wu, Qiulian; Bernatchez, Jean A.; Beck, Sungjun; Clark, Alex E.; Siqueira-Neto, Jair L.; Rich, Jeremy N.; McVicker, Graham published the artcile< Leveraging allele-specific expression for therapeutic response gene discovery in glioblastoma>, Related Products of 112-63-0, the main research area is temozolomide olaparib anticancer agent prognosis Zika virus glioblastoma adult.
Glioblastoma is the most prevalent primary malignant brain tumor in adults and is characterized by poor prognosis and universal tumor recurrence. Effective glioblastoma treatments are lacking, in part due to somatic mutations and epigenetic reprogramming that alter gene expression and confer drug resistance. To investigate recurrently dysregulated genes in glioblastoma, we interrogated allele-specific expression (ASE), the difference in expression between two alleles of a gene, in glioblastoma stem cells (GSC) derived from 43 patients. A total of 118 genes were found with recurrent ASE preferentially in GSCs compared with normal tissues. These genes were enriched for apoptotic regulators, including schlafen family member 11 (SLFN11). Loss of SLFN11 gene expression was associated with aberrant promoter methylation and conferred resistance to chemotherapy and PARP inhibition. Conversely, low SLFN11 expression rendered GSCs susceptible to the oncolytic flavivirus Zika. This discovery effort based upon ASE revealed novel points of vulnerability in GSCs, suggesting a potential alternative treatment strategy for chemotherapy-resistant glioblastoma.
Cancer Research published new progress about Adult, mammalian. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.
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