《Pentafluorobenzoylacetic ester》 was published in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1965. These research results belong to Prudchenko, A. T.; Barkhash, V. A.; Vorozhtsov, N. N. Jr.. Product Details of 4522-93-4 The article mentions the following:
C6F5CO2H heated with EtOH-H2SO4 11 hrs. gave 75.8% Et ester (I), b5 63°, n20D 1.4252. The reaction mixture prepared from 1.02 g. Mg, 4.9 ml. absolute EtOH, 0.1 ml. CCl4, and 6.5 g. CH2(CO2Et)2 in Et2O, was treated with 10 g. C6F5-COCl to yield 65% C6F5COCH(CO2Et),2, b6 137°, n25D 1.4620. The crude ester steam distilled in dilute H2SO4 gave 38% C6F5CO-CH2CO2Et (II) (b4 103.5°, n21D 1.4604), which heated with Ph-NH2 in xylene gave the anilide, m. 148°. The reaction mixture Of 3 g. Mg, 13.8 g. EtBr, and 12.84 g. iso-Pr2NH was treated with 5.31 g. EtOAc and 14.9 g. I 3 hrs. to yield, after quenching in ice-H2SO4, 43% II. AcCH2CO2Et treated with Na-EtOH, then evaporated in vacuo at 100° gave after treatment with I 3 hrs. at 140-5° and finally at 180°, followed by treatment with dilute H2SO4, 55.7% di-Et 2,3,5,6-tetrafluorohomoterephthalate (b5 141-2°, n25D 1.4590), which in 4 hrs. with aqueous KOH saponified to give 77.2% free acid, m. 220-1° (H2O). This heated with Me2NCHO 1 hr. at 130-40° gave 40.4% 2,3,5,6-tetrafluorophenylacetic acid, m. 140.5-1.5° (C6H6). Ir and N.M.R. spectra of the products were reported. In the experiment, the researchers used many compounds, for example, Ethyl 2,3,4,5,6-pentafluorobenzoate(cas: 4522-93-4Product Details of 4522-93-4)
Ethyl 2,3,4,5,6-pentafluorobenzoate(cas: 4522-93-4) belongs to esters.Product Details of 4522-93-4 They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics