Pommier, Agnes; Pons, Jean-Marc; Kocienski, Philip J. published the artcile< The First Total Synthesis of (-)-Lipstatin>, Electric Literature of 617-55-0, the main research area is asym synthesis lipstatin; stereoselective cycloaddition silylketene tetradecadienal.
A key step in the first total synthesis of the potent pancreatic lipase inhibitor (-)-lipstatin (I) is a diastereoselective Lewis acid-promoted [2 + 2] cycloaddition reaction between (trimethylsilyl)ketene Me(CH2)5C(SiMe3):CO and tetradecadienal II (TBS = Me3CSiMe2), which is prepared from di-Me (S)-(-)-malate.
Journal of Organic Chemistry published new progress about [2+2] Cycloaddition reaction. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Electric Literature of 617-55-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics