Peter, David; Brueckner, Reinhard published the artcile< Syntheses of a Pair of Simplified Model Compounds of the Dihydroxycyclopentenone Core of the Kodaistatins A-D>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is transition state kodaistatin synthon aldol condensation oxidation aldolization bromodiketone.
The kodaistatins A-D b are natural products from Aspergillus terreus with the potential of representing leads for a novel cure of type-2 diabetes. They possess an unusually and highly substituted dihydroxycyclopentenone core. Whether its OH groups are cis- or trans-configured remained unknown by spectroscopy. Previous syntheses of kodaistatin model compounds (cis-5, cis- and trans-6) allowed to make NMR comparisons with kodaistatin A. These findings are corroborated by the synthesis and ensuing NMR study of another pair of cis/trans-isomeric kodaistatin models (cis- and trans-7) described here. Its first key-step was a syn-selective aldol addition An oxidation/reduction sequence allowed reaching to the corresponding anti-aldol. Each aldol furnished a kodaistatin model in eight addnl. steps. The most noteworthy transformation was an SmII-induced intramol. aldolization of a bromodiketone.
European Journal of Organic Chemistry published new progress about Aldol addition. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics