Parmar, Karnjit; Haghshenas, Pouyan; Gravel, Michel published the artcile< Total Synthesis of (+)-Hyacinthacine A1 Using a Chemoselective Cross-Benzoin Reaction and a Furan Photooxygenation-Amine Cyclization Strategy>, Quality Control of 112-63-0, the main research area is chemoselective cross benzoin furan photooxygenation amine cyclization diastereoselective cascade; hyacinthacine A1 total synthesis.
We report the shortest synthesis of glycosidase inhibitor (+)-hyacinthacine A1 (I) using a highly chemoselective N-heterocyclic carbene-catalyzed cross-benzoin reaction as well as a furan photooxygenation-amine cyclization strategy. This is the first such cyclization on a furylic alc., an unprecedented reaction due to the notorious instability of the formed intermediates. The photooxygenation strategy was eventually incorporated into a three-step one-pot process that formed the requisite pyrrolizidine framework of (+)-hyacinthacine A1.
Organic Letters published new progress about Benzoin condensation reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.
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