Maimo-Barcelo, Albert; Martin-Saiz, Lucia; Fernandez, Jose A.; Perez-Romero, Karim; Garfias-Arjona, Santiago; Lara-Almunia, Monica; Pierola-Lopetegui, Javier; Bestard-Escalas, Joan; Barcelo-Coblijn, Gwendolyn published the artcile< Polyunsaturated Fatty Acid-Enriched Lipid Fingerprint of Glioblastoma Proliferative Regions Is Differentially Regulated According to Glioblastoma Molecular Subtype>, Quality Control of 112-63-0, the main research area is Glioblastoma proliferative region polyunsaturated fatty acid lipid fingerprint; MALDI-IMS lipidomics; glioblastoma; lipid metabolism; modular gene expression; molecular subtypes; temozolomide.
Glioblastoma (GBM) represents one of the deadliest tumors owing to a lack of effective treatments. The adverse outcomes are worsened by high rates of treatment discontinuation, caused by the severe side effects of temozolomide (TMZ), the reference treatment. Therefore, understanding TMZ′s effects on GBM and healthy brain tissue could reveal new approaches to address chemotherapy side effects. In this context, we have previously demonstrated the membrane lipidome is highly cell type-specific and very sensitive to pathophysiol. states. However, little remains known as to how membrane lipids participate in GBM onset and progression. Hence, we employed an ex vivo model to assess the impact of TMZ treatment on healthy and GBM lipidome, which was established through imaging mass spectrometry techniques. This approach revealed that bioactive lipid metabolic hubs (phosphatidylinositol and phosphatidylethanolamine plasmalogen species) were altered in healthy brain tissue treated with TMZ. To better understand these changes, we interrogated RNA expression and DNA methylation datasets of the Cancer Genome Atlas database. The results enabled GBM subtypes and patient survival to be linked with the expression of enzymes accounting for the observed lipidome, thus proving that exploring the lipid changes could reveal promising therapeutic approaches for GBM, and ways to ameliorate TMZ side effects.
International Journal of Molecular Sciences published new progress about 5-Lipoxygenase-activating protein inhibitors. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.
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