Kvasnica, M.; Oklestkova, J.; Bazgier, V.; Rarova, L.; Korinkova, P.; Mikulik, J.; Budesinsky, M.; Beres, T.; Berka, K.; Lu, Q.; Russinova, E.; Strnad, M. published the artcile< Design, synthesis and biological activities of new brassinosteroid analogues with a phenyl group in the side chain>, COA of Formula: C19H34O2, the main research area is brassinolide analog preparation plant hormone antitumor agent cytotoxicity; etiolated pea seedlings plant hormone ethylene production differences.
We have prepared and studied a series of new brassinosteroid derivatives with a p-substituted Ph group in the side chain. To obtain the best comparison between mol. docking and biol. activities both types of brassinosteroids were synthesized; 6-ketones, 10 examples, and B-lactones, 8 examples. The Ph group was introduced into the steroid skeleton by Horner-Wadsworth-Emmons. The docking studies were carried out using AutoDock Vina 1.05. Plant biol. activities were established using different brassinosteroid bioassays in comparison with natural brassinosteroids. Differences in the production of the plant hormone ethylene were also observed in etiolated pea seedlings after treatment with new brassinosteroids. The most active compounds were lactone I and 6-oxo derivatives II [R2 = H, F], their biol. activities were comparable or even better than naturally occurring brassinolide. Finally the cytotoxicity of the new derivatives was studied using human normal and cancer cell lines.
Organic & Biomolecular Chemistry published new progress about Antiproliferative agents (weak to moderate). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics