Jatyan, Reena; Singh, Prabhjeet; Sahel, Deepak Kumar; Karthik, Y. G.; Mittal, Anupama; Chitkara, Deepak published the artcile< Polymeric and small molecule-conjugates of temozolomide as improved therapeutic agents for glioblastoma multiforme>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is review glioblastoma multiforme temozolomide therapeutic agent bioavailability nanocarrier liposome; Glioblastoma Multiforme; Polymer drug conjugates; Prodrugs; Small molecules; Temozolomide.
A review. Temozolomide (TMZ), an imidazotetrazine, is a second-generation DNA alkylating agent used as a first-line treatment of glioblastoma multiforme (GBM). It was approved by FDA in 2005 and declared a blockbuster drug in 2008. Although TMZ has shown 100% oral bioavailability and crosses the blood-brain barrier effectively, however it suffers from limitations such as a short half-life (∼1.8 h), rapid metabolism, and lesser accumulation in the brain (∼10-20%). Addnl., development of chemoresistance has been associated with its use. Since it is a potential chemotherapeutic agent with an unmet medical need, advanced delivery strategies have been explored to overcome the associated limitations of TMZ. Nanocarriers including liposomes, solid lipid nanoparticles (SLNs), nanostructure lipid carriers (NLCs), and polymeric nanoparticles have demonstrated their ability to improve its circulation time, stability, tissue-specific accumulation, sustained release, and cellular uptake. Because of the appreciable water solubility of TMZ (∼5 mg/mL), the phys. loading of TMZ in these nanocarriers is always challenging. Alternatively, the conjugation approach, wherein TMZ has been conjugated to polymers or small mols., has been explored with improved outcomes in vitro and in vivo. This review emphasized the practical evidence of the conjugation strategy to improve the therapeutic potential of TMZ in the treatment of glioblastoma multiforme.
Journal of Controlled Release published new progress about Bioavailability. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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