Gu, Yiyu; Lu, Xiaoqing; Ma, Xiaodong; Zhang, Haojian; Ji, Yuanyuan; Ding, Wanjing; Shen, Li published the artcile< Design, synthesis and biological evaluation of (quinolinyl-3-pyridinyl) benzenesulfonamide-based hydroxamic acids as PI3K and HDAC dual targeting inhibitors>, Reference of 112-63-0, the main research area is quinolinylpyridinylbenzenesulfonamide hydroxamic acid PI 3K HDAC targeting inhibitor.
Polypharmacol. has emerged as a promising approach to drug discovery, especially antitumor drug. This study reports the design, synthesis, and biol. evaluation of novel phosphatidylinositol 3-kinases (PI3Ks) and histone deacetylases (HDACs) dual inhibitors on the basis of GSK2126458 under clin. evaluation and vorinostat approved. Among these hybrid mols., GYB-4 and GYB-5 possessed potent inhibition against both PI3Kα (1.0 and 1.3 nmol/L, resp.) and HDAC1 (4.2 and 4.8 nmol/L, resp.). Antiproliferative assays with HCT116, PC3 and A2780 cell lines subsequently were performed. The structure-activity relationship study will guide to optimization of dual PI3K and HDAC inhibitors.
Youji Huaxue published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics