Dolan, Niamh; Gavin, Declan P.; Eshwika, Ahmed; Kavanagh, Kevin; McGinley, John; Stephens, John C. published the artcile< Synthesis, antibacterial and anti-MRSA activity, in vivo toxicity and a structure-activity relationship study of a quinoline thiourea>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is quinoline thiourea preparation antibacterial structure activity; Antibacterial; MRSA; Quinoline; Structure activity relationship; Thiourea.
We report the synthesis and antibacterial evaluation of a series of thiourea-containing compounds 1-[3,5-Bis(trifluoromethyl)phenyl]-[(quinuclidin-2-yl)methyl]thiourea I, was the most active against a range of Gram-pos. and Gram-neg. bacteria, and exhibited bacteriostatic activity against methicillin resistant Staphylococcus aureus (MRSA) comparable to that of the well-known antibacterial agent vancomycin. Quinoline thiourea I was subjected to a detailed structure-activity relationship study, with I and its derivatives evaluated for their bacteriostatic activity against both Gram-neg. and Gram-pos. bacteria. A number of structural features important for the overall activity of quinoline thiourea I have been identified. A selection of compounds, including I, was also evaluated for their in vivo toxicity using the larvae of the Greater wax moth, Galleria mellonella. Compound I, and a number of derivatives, were found to be non-toxic to the larvae of Galleria mellonella. A new class of antibiotic can result from the further development of this family of compounds
Bioorganic & Medicinal Chemistry Letters published new progress about Antibacterial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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