In 2019,Journal of the American Chemical Society included an article by Boyington, Allyson J.; Seath, Ciaran P.; Zearfoss, Avery M.; Xu, Zihao; Jui, Nathan T.. Quality Control of tert-Butyl carbamate. The article was titled 《Catalytic Strategy for Regioselective Arylethylamine Synthesis》. The information in the text is summarized as follows:
A mild, modular, and practical catalytic system for the synthesis of the highly privileged phenethylamine pharmacophore is reported. Using a unique combination of organic catalysts to promote the transfer of electrons and hydrogen atoms, this system performs direct hydroarylation of vinyl amine derivatives with a wide range of aryl halides (including aryl chlorides). This general and highly chemoselective protocol delivers a broad range of arylethylamine products with complete regiocontrol. The utility of this process is highlighted by its scalability and the modular synthesis of an array of bioactive small mols. In the experiment, the researchers used many compounds, for example, tert-Butyl carbamate(cas: 4248-19-5Quality Control of tert-Butyl carbamate)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Quality Control of tert-Butyl carbamate
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Ester – Wikipedia,
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