Betti, Matteo; Castagnoli, Giulio; Panico, Alessandro; Sanna-Coccone, Salvatore; Wiedenau, Paul published the artcile< Development of a Scalable Route to the SMO Receptor Antagonist SEN794>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is scalable route Smoothened receptor antagonist SEN794.
A practical and scalable route to the SMO receptor antagonist SEN794 1 is described herein. A new and efficient access to the key intermediate 7 via the Kroehnke reaction was developed, significantly simplifying the synthesis and reducing costs. The optimized route consists of six chem. steps plus a palladium scavenging step. The intermediates are solids and were isolated by filtrations, except for ester 9, which was telescoped as the crude oil into the subsequent step. In the final amide formation step, target compound 1 was conveniently crystallized from the reaction mixture in high purity.
Organic Process Research & Development published new progress about Krohnke pyridine synthesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics