Al-Hussaini, Jinan Abdul-Amir Sabeeh; Hatem, Oraas Adnan; Alebady, Zainab Adnan Hatem published the artcile< Determination of chemical potential for stavudine (D4T) diffusion through SDS micelle solution>, Reference of 112-63-0, the main research area is chem potential stavudine cell membrane diffusion SDS micelle solution.
This study include a spectroscopic measurements of Stavudine diffusion in cell membrane alternative model in two different polar solutions; buffer phosphate solution (Polar solution) and N-Hexane (Non-polar solution). Consistent with the standard values, a clear maximum absorption peaks at 266 nm was noted for Stavudine in buffer phosphate solution The data also showed that the value of the extension coefficient and λmaxreduced in the non-polar medium compare to polar medium which was noted a s a part of the spectroscopic properties of Stavudine in polar and non-polar medium. Stavudine express a high stability with time in pH 7.4 . SDS was used as a cell membranes substitute model, and the diffusion rate of Stavudine through SDS micelles solution (with a concentration of 0.2 x10-2 M)was examined The chem. potential was calculated which was equal to -2489.4 J mol-1 which indicate the impulsiveness of the diffusion process for the compound The results suggested that Stavudine can diffuse (in a rate constant of 0.0183 min-1)to inside micelle from the aqueous medium. Of other detected factors; the equilibrium constant for diffusion rate was detected and was equal to 2.7313.
Systematic Reviews in Pharmacy published new progress about Cell membrane. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.
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