Yang, Baochao; Wen, Guoen; Zhang, Quan; Hou, Min; He, Haibing; Gao, Shuanhu published the artcile< Asymmetric Total Synthesis and Biosynthetic Implications of Perovskones, Hydrangenone, and Hydrangenone B>, COA of Formula: C19H34O2, the main research area is asym total synthesis biosynthesis perovskone hydrangenone; photoenolization Diels Alder icetexane synthesis; bioinspired Diels Alder perovskatone D ocimene perovskone synthesis.
Perovskones and hydrangenones are a family of structurally complex triterpenoids that were mainly isolated from the genus Salvia medicinal plants. These isoprenoids exhibit a broad range of biol. activities, such as antitumor and antiplasmodial activities. Here, we report the collective total synthesis of perovskone (I), perovskones C (II), D (III), F (IV), hydrangenone (V), and hydrangenone B (VI). The key strategies in this work include the following: (1) an asym. photoenolization/Diels-Alder reaction was developed to construct a tricyclic ring bearing three contiguous quaternary centers, which was used to build the core icetexane skeleton; (2) a bioinspired Diels-Alder reaction of perovskatone D with trans-α-ocimene was applied to stereospecifically generate perovskones; (3) late-stage oxidations and ring forming steps were developed to synthesize perovskones and hydrangenones. Our synthetic work suggests that (1) perovskatone D may serve as the precursor of the biosynthesis of perovskones and (2) the formation of hydrangenone and hydrangenone B, containing a five-membered D ring, may involve an oxidative ring cleavage and ring regeneration process.
Journal of the American Chemical Society published new progress about Acetalization (1-pot stereoselective Diels-Alder/hemiacetalization cascade). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics