Xu, Chunfa; Ma, Bingqing; Shen, Qilong published the artcile< N-[(Trifluoromethyl)thio]saccharin: An Easily Accessible, Shelf-Stable, Broadly Applicable Trifluoromethylthiolating Reagent>, Category: esters-buliding-blocks, the main research area is electrophilic substitution sulfur fluorine; NMR spectroscopy; electrophilic substitution; fluorine; sulfur; synthetic methods.
A new, electrophilic trifluoromethylthiolaton agent N-[(trifluoromethyl)thio]saccharin, was developed and can be synthesized in two steps from saccharin within 30 min. N-[(trifluoromethyl)thio]saccharin is a powerful trifluoromethylthiolation agent and allows the trifluoromethylthiolation of a variety of nucleophiles such as alcs., amines, thiols, electron-rich arenes, aldehydes, ketones, acyclic β-keto esters, and alkynes under mild reaction conditions. The synthesis of the target compounds was achieved using 2-[(trifluoromethyl)thio]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide as a key reactant.
Angewandte Chemie, International Edition published new progress about Active methylene compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.
Referemce:
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