Xia, Yi; Yang, Zheng-Yu; Xia, Peng; Bastow, Kenneth F.; Nakanishi, Yuka; Nampoothiri, Priya; Hamel, Ernest; Brossi, Arnold; Lee, Kuo-Hsiung published the artcile< Antitumor agents. Part 226: Synthesis and cytotoxicity of 2-phenyl-4-quinolone acetic acids and their esters>, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate, the main research area is phenylquinoloneacetic acid preparation antitumor agent cytotoxicity.
2-Phenyl-4-quinolone acetic acids and their esters were synthesized and evaluated for interaction with tubulin and for cytotoxicity against a panel of human tumor cell lines. 2-Phenyl- and 2-(2′-fluorophenyl)-4-quinolone-8-acetic acids displayed potent cytotoxicity with ED50 values at nanomolar concentrations, but had minimal activity against tubulin polymerization 2-(2′-Fluorophenyl)-4-quinolone-6-acetic acid and 2-(2′-fluorophenyl)-4-quinolone-8-acetic acid Me ester moderately inhibited tubulin polymerization
Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics