Wilkerson, Jenny L.; Felix, Jasmine S.; Bilbrey, Joshua A.; McCurdy, Christopher R.; McMahon, Lance R. published the artcile< Characterization of a mouse neuropathic pain model caused by the highly active antiviral therapy (HAART) Stavudine>, HPLC of Formula: 112-63-0, the main research area is stavudine highly active antiviral therapy neuropathic pain model; HIV; Neuropathic pain; Opioid.
Although highly active antiviral therapies (HAART) exert control over viral replication in persons with Acquired Immunodeficiency Syndrome (AIDS), neuropathic pain is a side effect. Symptoms include hyperalgesia and allodynia. Stavudine, also known as D4T, is a HAART used to treat Human Immunodeficiency Virus (HIV). This study examined the extent to which D4T produces neuropathic pain and examined pharmacol. management with a standard opioid analgesic. Male and female C57BL/6 J mice were injected i.p. with one dose of vehicle or D4T (10-56 mg/kg). Mice were tested through day 92 post injection for mech. allodynia, assessed with von Frey filaments, and thermal hyperalgesia, assessed via the hotplate test. Sep. cohorts received vehicle or 56 mg/kg D4T, the presence of allodynia and thermal hyperalgesia confirmed, and mice received i.p. vehicle, morphine, or 0.032 mg/kg naltrexone + morphine. D4T produced dose- and time-dependent mech. allodynia and thermal hyperalgesia. The smallest effective D4T dose was 17.8 mg/kg. This dose produced mech. allodynia but not thermal hyperalgesia. Larger D4T doses (32 and 56 mg/kg) produced mech. allodynia and thermal hyperalgesia lasting 92 days. Morphine dose-dependently alleviated both mech. allodynia and thermal hyperalgesia in D4T-treated mice with ED50 values of 4.4 and 1.2 mg/kg, resp. Naltrexone produced a rightward shift of the morphine dose-response function, i.e., increased the ED50 value of morphine by at least 3.8-fold. Stavudine produced neuropathic pain as a function of dose and time in mice. Opioid analgesics appear to be effective in alleviating neuropathic pain in a D4T-induced mouse model.
Pharmacological Reports published new progress about AIDS (disease). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.
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