Wang, Jianhua; Li, Xiaoxun published the artcile< Asymmetric β-arylation of cyclopropanols enabled by photoredox and nickel dual catalysis>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is beta aryl ketone preparation enantioselective; cyclopropanol aryl bromide beta arylation photoredox nickel catalyst.
The enantioselective functionalization and transformation of readily available cyclopropyl compounds are synthetically appealing yet challenging topics in organic synthesis. Here authors report an asym. β-arylation of cyclopropanols with aryl bromides enabled by photoredox and nickel dual catalysis. This dual catalytic transformation features a broad substrate scope and good functional group tolerance at room temperature, providing facile access to a wide array of enantioenriched β-aryl ketones bearing a primary alc. moiety in good yields with satisfactory enantioselectivities (39 examples, up to 83% yield and 90% ee). The synthetic value of this protocol was illustrated by the concise asym. construction of natural product calyxolane B analogs.
Chemical Science published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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