Wagnieres, Olivier; Xu, Zhengren; Wang, Qian; Zhu, Jieping published the artcile< Unified Strategy to Monoterpene Indole Alkaloids: Total Syntheses of (±)-Goniomitine, (±)-1,2-Dehydroaspidospermidine, (±)-Aspidospermidine, (±)-Vincadifformine, and (±)-Kopsihainanine A>, Product Details of C9H9NO4, the main research area is stereoselective synthesis monoterpene indole alkaloid; goniomitine stereoselective synthesis; dehydroaspidospermidine stereoselective synthesis; aspidospermidine vincadifformine kopsihainanine stereoselective synthesis; decarboxylative vinylation palladium catalyst monoterpene indole alkaloid synthesis; oxidation reduction cyclization integrated stereoselective synthesis monoterpene indole alkaloid.
Total syntheses of (±)-goniomitine, (±)-1,2-dehydroaspidospermidine, (±)-aspidospermidine, (±)-vincadifformine, and (±)-kopsihainanine A were achieved featuring two common key steps: (1) a palladium-catalyzed decarboxylative vinylation that provides quick access to cyclopentene intermediates containing all of the carbons present in the natural products and (2) an integrated oxidation/reduction/cyclization (iORC) sequence for skeletal reorganization that converts the cyclopentenes to the pentacyclic structures of the natural products. By incorporation of a geometric constraint to iORC substrates, both the chemoselectivity (C7 vs. N1 cyclization) and the stereoselectivity (trans- vs. cis-fused ring system) of the cyclization process can be controlled.
Journal of the American Chemical Society published new progress about Cyclization. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Product Details of C9H9NO4.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics