Temburnikar, Kartik W.; Zimmermann, Sarah C.; Kim, Nathaniel T.; Ross, Christina R.; Gelbmann, Christopher; Salomon, Christine E.; Wilson, Gerald M.; Balzarini, Jan; Seley-Radtke, Katherine L. published the artcile< Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is antiproliferative activity cancer fungus halogenated thienopyrimidine structure; Antifungal; Apoptosis; Cytostatic; Heterocyclic chemistry; Thieno[3,2-d]pyrimidine.
The in vitro evaluation of thieno[3,2-d]pyrimidines identified halogenated compounds 1 and 2 with antiproliferative activity against three different cancer cell lines. A structure activity relation study indicated the necessity of the chlorine at the C4-position for biol. activity. The two most active compounds 1 and 2 were found to induce apoptosis in the leukemia L1210 cell line. Addnl., the compounds were screened against a variety of other microbial targets and as a result, selective activity against several fungi was also observed The synthesis and preliminary biol. results are reported herein.
Bioorganic & Medicinal Chemistry published new progress about Antibacterial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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Ester – an overview | ScienceDirect Topics