Takeuchi, Toshifumi; Dobashi, Akira; Kimura, Kanako published the artcile< Molecular Imprinting of Biotin Derivatives and Its Application to Competitive Binding Assay Using Nonisotopic Labeled Ligands>, Application of C19H34O2, the main research area is mol imprinting biotin nonisotopic labeled ligand; polymer based competitive binding assay.
Synthetic biotin-binding polymers were prepared by mol. imprinting. Methacrylic acid (MAA) was copolymerized with ethylene glycol dimethacrylate in the presence of biotin Me ester (B-Me) in chloroform. Hydrogen-bonding-based complexation of B-Me with MAA generates the binding sites complementary to B-Me after extracting B-Me from the resulting copolymers. Data from NMR titration suggest a one-to-one prepolymerization complex formation of B-Me with MAA in chloroform. A possible complex structure was estimated by docking of the most stable conformers by intermol. Monte Carlo conformational search under the assumption of a one-to-one association The selectivity of the imprinted polymers was investigated and an imprinted polymer-based competitive binding assay for B-Me was demonstrated using biotin p-nitrophenyl ester as a nonisotopic-labeled ligand.
Analytical Chemistry published new progress about Analysis (polymer-based competitive binding assay). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics