Sun, Rui; Lei, Chao; Chen, Liang; He, Liqing; Guo, Haixun; Zhang, Xiang; Feng, Wenke; Yan, Jun; McClain, Craig J.; Deng, Zhongbin published the artcile< Alcohol-driven metabolic reprogramming promotes development of RORγt-deficient thymic lymphoma>, Computed Properties of 112-63-0, the main research area is thymic lymphoma RORgammat alc metabolism.
RORγt is a master regulator of Th17 cells. Despite evidence linking RORγt deficiency/inhibition with metastatic thymic T cell lymphomas, the role of RORγt in lymphoma metabolism is unknown. Chronic alc. consumption plays a causal role in many human cancers. The risk of T cell lymphoma remains unclear in humans with alc. use disorders (AUD) after chronic RORγt inhibition. Here we demonstrated that alc. consumption accelerates RORγt deficiency-induced lymphomagenesis. Loss of RORγt signaling in the thymus promotes aerobic glycolysis and glutaminolysis and increases allocation of glutamine carbon into lipids. Importantly, alc. consumption results in a shift from aerobic glycolysis to glutaminolysis. Both RORγt deficiency- and alc.-induced metabolic alterations are mediated by c-Myc, as silencing of c-Myc decreases the effects of alc. consumption and RORγt deficiency on glutaminolysis, biosynthesis, and tumor growth in vivo. The ethanol-mediated c-Myc activation coupled with increased glutaminolysis underscore the critical role of RORγt-Myc signaling and translation in lymphoma.
Oncogene published new progress about Alcoholism. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics