Li, Lin; Wang, Hui; Zhao, Shuping; Zhao, Yuan; Chen, Yongping; Zhang, Jiuyan; Wang, Chuqiao; Sun, Ning; Fan, Honggang published the artcile< Paeoniflorin ameliorates lipopolysaccharide-induced acute liver injury by inhibiting oxidative stress and inflammation via SIRT1 / FOXO1a / SOD2 signaling in rats>, HPLC of Formula: 112-63-0, the main research area is inflammation oxidative stress paeoniflorin ameliorates lipopolysaccharide acute liver injury; NLRP3 inflammasome; Paeoniflorin; SIRT1/FOXO1a/SOD2 signaling; acute liver injury; mitochondrial ROS.
Acute liver injury (ALI) is a poor prognosis and high mortality complication of sepsis. Paeoniflorin (PF) has remarkable anti-inflammatory effects in different disease models. Here, we explored the protective effect and underlying mol. mechanisms of PF against lipopolysaccharide (LPS)-induced ALI. Sprague-Dawley rats received i.p. (i.p.) injection of PF for 7 days, 1 h after the last administration, and rats were injected i.p. 10 mg/kg LPS. PF improved liver structure and function, reduced hepatic reactive oxygen species (ROS) and methane dicarboxylic aldehyde (MDA) levels, and increased superoxide dismutase (SOD) activity. Western blot anal. suggested that PF significantly inhibited expression of inflammatory cytokines (TNF-α, IL-1β, and IL-18) and inhibited activation of the NLRP3 inflammasome. PF or mitochondrial ROS scavenger (mito-TEMPO) significantly improved liver mitochondrial function by scavenging mitochondrial ROS (mROS), restoring mitochondrial membrane potential loss and increasing level of ATP and enzyme activity of complex I and III. In addition, PF increased expression of sirtuin-1 (SIRT1), forkhead box O1 (FOXO1a) and manganese superoxide dismutase (SOD2), and increased FOXO1a nuclear retention. However, the inhibitor of SIRT1 (EX527) abolished the protective effect of PF. Taken together, PF promotes mROS clearance to inhibit mitochondrial damage and activation of the NLRP3 inflammasome via SIRT1/FOXO1a/SOD2 signaling.
Phytotherapy Research published new progress about Acute liver failure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.
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