Knauer, Nadezhda; Arkhipova, Valeria; Li, Guanzhang; Hewera, Michael; Pashkina, Ekaterina; Nguyen, Phuong-Hien; Meschaninova, Maria; Kozlov, Vladimir; Zhang, Wei; Croner, Roland S.; Caminade, Anne-Marie; Majoral, Jean-Pierre; Apartsin, Evgeny K.; Kahlert, Ulf D. published the artcile< In Vitro Validation of the Therapeutic Potential of Dendrimer-Based Nanoformulations against Tumor Stem Cells>, Electric Literature of 112-63-0, the main research area is dendrimer nanoformulation tumor stem cell therapeutic target; 3D tumor models; Lyn; dendrimers; nanomedicine; nucleic acid therapeutics; phosphorus; polyelectrolyte complexes; tumor stem cells.
Tumor cells with stem cell properties are considered to play major roles in promoting the development and malignant behavior of aggressive cancers. Therapeutic strategies that efficiently eradicate such tumor stem cells are of highest clin. need. Herein, we performed the validation of the polycationic phosphorus dendrimer-based approach for small interfering RNAs delivery in in vitro stem-like cells as models. As a therapeutic target, we chose Lyn, a member of the Src family kinases as an example of a prominent enzyme class widely discussed as a potent anti-cancer intervention point. Our selection is guided by our discovery that Lyn mRNA expression level in glioma, a class of brain tumors, possesses significant neg. clin. predictive value, promoting its potential as a therapeutic target for future mol.-targeted treatments. We then showed that anti-Lyn siRNA, delivered into Lyn-expressing glioma cell model reduces the cell viability, a fact that was not observed in a cell model that lacks Lyn-expression. Furthermore, we have found that the dendrimer itself influences various parameters of the cells such as the expression of surface markers PD-L1, TIM-3 and CD47, targets for immune recognition and other biol. processes suggested to be regulating glioblastoma cell invasion. Our findings prove the potential of dendrimer-based platforms for therapeutic applications, which might help to eradicate the population of cancer cells with augmented chemotherapy resistance. Moreover, the results further promote our functional stem cell technol. as suitable component in early stage drug development.
International Journal of Molecular Sciences published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.
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