Gilligan, Paul J.; Folmer, Beverly K.; Hartz, Richard A.; Koch, Stephanie; Nanda, Kausik K.; Andreuski, Stephen; Fitzgerald, Lawrence; Miller, Keith; Marshall, William J. published the artcile< Pyrazolo-[1,5-a]-1,3,5-triazine corticotropin-releasing factor (CRF) receptor ligands>, HPLC of Formula: 112-63-0, the main research area is pyrazolotriazine preparation corticotropin releasing factor receptor ligand.
The syntheses and rat CRF receptor binding affinities of retro-pyrazolotriazine’ corticotropin-releasing factor (CRF) ligands are reported. Some have high affinity for rat CRF receptors (Ki≤10 nM). The data provide addnl. support for the hypothesis that it is possible to interchange isosteric cores with similar electronic properties in the design of high-affinity CRF receptor ligands, provided the peripheral pharmacophore elements are maintained in the same three-dimensional array.
Bioorganic & Medicinal Chemistry published new progress about Corticotropin releasing factor receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics