Bertus, Philippe; Zhang, Jing-Heng; Sir, Geoffroy; Weibel, Jean-Marc; Pale, Patrick published the artcile< Asymmetric synthesis of the cyclopentanones related to NCS and N1999A2 antitumor antibiotics>, Safety of (S)-Dimethyl 2-hydroxysuccinate, the main research area is hydroxylated cyclopentanone Bestmann cyclization preparation; NCS N1999A2 hydroxylated cyclopentanone core preparation.
Optically pure protected mono- or dihydroxylated cyclopentanones, precursors for the core of the antitumor antibiotics NCS and N1999A2 were obtained in six to eight steps via a key Bestmann cyclization with excellent overall yields (up to 52%).
Tetrahedron Letters published new progress about Cyclization. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Safety of (S)-Dimethyl 2-hydroxysuccinate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics