Yousfi, F. Z.; Boutahiri, N.; Ouerdja, I.; Rguig, N.; Nader, S.; Aharmim, M.; Bourkadi, J. E. published the artcile< Multi-Drug Resistant Tuberculosis and HIV Infection about 06 Cases>, Computed Properties of 112-63-0, the main research area is diagnosis risk factor HIV infection multidrug resistant tuberculosis.
Multi-drug-resistant tuberculosis remains a significant threat in people living with HIV and promotes increased mortality rates. It is often a combination of pulmonary tuberculosis forms and extra-pulmonary forms. We report 6 cases of patients with HIV and multi-drug-resistant tuberculosis collected over a two-year period from 01/01/2018 to 31/12/2019 hospitalized for multi-drug-resistant tuberculosis at Moulay Youssef Hospital. We describe the radiol., evolutionary and therapeutic clin. characteristics of resistant TB in this patient category. The average age of our patients was 36. These are 2 women and 4 men. Of which 4 were known to carry retroviral infection, followed and treated with antiretroviral therapy, there was only one diabetic patient on insulin therapy. The signs of calls were respiratory in 3 patients, digestive in one patient, neurol. in one case, and an alteration of the general state in the last case. Exclusive pulmonary involvement was noted in 4 patients, associated with neuromeningeal localization in one patient and cervical lymph node localization in the last case The radiol. aspect was dominated by bilateral micronodular opacities often associated with sequellary opacities. Based on the results of the xpert Tb Rif and Hain Test 1 st line and 2 nd line 3 cases of our patients were Prexdr (resistant to injectable 1/3 cases, resistant to furoquinolone 2/3 cases), MDR in one patient, two patients were classified as RR due to the unavailability of genotypic tests. The evolution during hospitalization was marked by the occurrence of pneumocystosis in 2 patients who had progressed well under Bactrim high curative dose and systemic corticosteroids, pneumothorax in one case; we deplore the death of a patient by tuberculosis meningitis. Five patients were put individualized regimen of 20-24 mo and only one case on a standardized regimen for 9-11 mo, antiretroviral treatment was initiated after 1 mo of the start of anti-bacillary treatment in 2 cases (CD4 rate > 500). Major adverse effects were observed in 3 patients. These were bilateral deafness, significant hepatic cytolysis, and severe cytopenia which required the permanent discontinuation of amikacin, Pza, Linezolid resp. Minor side effects, a type of digestive intolerance, were noted in 2 patients who progressed well under symptomatic treatment. Minor side effects, a type of digestive intolerance, were noted in 2 patients who progressed well under symptomatic treatment.HIV infection increases the risk of the emergence of resistant strains of the TB bacillus in HIV-pos. subjects. The combination of multi-drug-resistant tuberculosis and HIV infection is a major risk factor for morbidity-mortality.
Elixir International Journal published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.
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