Tchani, G.; Baziard-Mouysset, G.; Younes, S.; Bellan, J.; Payard, M.; Stigliani, J. L.; Grassy, G.; Bonnafous, R.; Tisne-Versailles, J. published the artcile< Evaluation of calcium inhibitory activity of a series of diethyl benzylphosphonates>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is calcium antagonist benzylphosphonate; structure activity relationship calcium channel blocking; cardiodepressive benzylphosphonate.
Thirty-nine di-Et benzylphosphonates (12 newly prepared) related to Fostedil were evaluated as calcium antagonists, using the inhibition test on aortic contraction in the rabbit, which was more selective than the neg. inotropic activity test on guinea-pig left atrial muscle. Six compounds had weak activity compared with Fostedil. Structure-activity relationships indicated a certain lipophilic influence; no correlation was found with electronic parameters. The prerequisite structure to obtain active products seems to require two conjugated aromatic rings separated by an optimal distance.
European Journal of Medicinal Chemistry published new progress about Calcium channel blockers. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics