Luo, Yunxia; Chen, Hansen; Tsoi, Bun; Wang, Qi; Shen, Jiangang published the artcile< Danggui-Shaoyao-San (DSS) ameliorates cerebral ischemia-reperfusion injury via activating SIRT1 signaling and inhibiting NADPH oxidases>, Electric Literature of 112-63-0, the main research area is DSS cerebral ischemia reperfusion injury SIRT signaling NADPH oxidase; Danggui-Shaoyao-San; SIRT1; oxidative stress; peroxynitrite; stroke.
Danggui-Shayao-San (DSS) is a famous Traditional Chinese Medicine formula that used for treating pain disorders and maintaining neurol. health. Recent studies indicate that DSS has neuroprotective effects against ischemic brain damage but its underlining mechanisms remain unclear. Herein, we investigated the neuroprotective mechanisms of DSS for treating ischemic stroke. Adult male Sprague-Dawley (S.D.) rats were subjected to 2 h of middle cerebral artery occlusion (MCAO) plus 22 h of reperfusion. Both ethanol extract and aqueous extract of DSS (12 g/kg) were orally administrated into the rats at 30 min prior to MCAO ischemic onset. We found that 1 ethanol extract of DSS, instead of aqueous extract, reduced infarct sizes and improved neurol. deficit scores in the post-ischemic stroke rats; 2 Ethanol extract of DSS down-regulated the expression of the cleaved-caspase 3 and Bax, up-regulated bcl-2 and attenuated apoptotic cell death in the ischemic brains; 3 Ethanol extract of DSS decreased the production of superoxide and peroxynitrite; 4 Ethanol extract of DSS significantly down-regulated the expression of p67phox but has no effect on p47phox and iNOS statistically. 5 Ethanol extract of DSS significantly up-regulated the expression of SIRT1 in the cortex and striatum of the postischemic brains; 6 Co-treatment of EX527, a SIRT1 inhibitor, abolished the DSS’s neuroprotective effects. Taken together, DSS could attenuate oxidative/nitrosative stress and inhibit neuronal apoptosis against cerebral ischemic-reperfusion injury via SIRT1-dependent manner.
Frontiers in Pharmacology published new progress about Animal gene, Bcl-2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.
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