Leivers, Anna L.; Tallant, Matthew; Shotwell, J. Brad; Dickerson, Scott; Leivers, Martin R.; McDonald, Octerloney B.; Gobel, Jeff; Creech, Katrina L.; Strum, Susan L.; Mathis, Amanda; Rogers, Sabrinia; Moore, Chris B.; Botyanszki, Janos published the artcile< Discovery of Selective Small Molecule Type III Phosphatidylinositol 4-Kinase Alpha (PI4KIIIα) Inhibitors as Anti Hepatitis C (HCV) Agents>, Electric Literature of 112-63-0, the main research area is arylaminosulfonylpyridinyl arylsulfonylaminopyridinyl aminoquinazolinone preparation PI4KIII alpha aminoquinoxaline aminonaphthyridine inhibitor; structure arylaminosulfonylpyridinyl arylsulfonylaminopyridinyl aminoquinazolinone inhibition PI4KIII alpha selectivity; inhibition hepatitis C virus replication arylaminosulfonylpyridinyl arylsulfonylaminopyridinyl aminoquinazolinone; toxicity nonracemic arylaminosulfonylpyridinyl aminoquinazolinone PI4KIII alpha inhibitor.
Arylaminosulfonylpyridinyl and arylsulfonylaminopyridinyl aminoquinazolinones such as I and related aminonaphthyridines and an aminoquinoxaline were prepared as inhibitors of the type III phosphatidylinositol-4-kinase α (PI4KIIIα), a lipid kinase that interacts with the HCV nonstructural 5A protein and enriches the HCV replication complex with phosphatidylinositol 4-phosphate, for use in the treatment of hepatitis C infection by inhibiting hepatitis C replication. The inhibition of PI4KIIIα by arylaminosulfonylpyridinyl and arylsulfonylamino aminoquinazolinones, arylsulfonylaminopyridinyl aminonaphthyridines, and an arylsulfonylaminopyridinyl aminoquinoxaline and their selectivities for PI4KIIIα over related phosphatidylinositol-3-kinase isoforms were determined The PI4KIIIα inhibition of I, its enantiomer, and the racemate were compared; the pharmacokinetics for I and its enantiomer were determined and toxicity was seen in rats given either one 50 mg/kg dose or multiple 40 mg/kg doses.
Journal of Medicinal Chemistry published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.
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