Khan, Ali; Pervaiz, Aini; Ansari, Bushra; Ullah, Riaz; Shah, Syed Muhammad Mukarram; Khan, Haroon; Saeed Jan, Muhammad; Hussain, Fida; Ijaz Khan, Mohammad; Albadrani, Ghadeer M.; Altyar, Ahmed E.; Abdel-Daim, Mohamed M. published the artcile< Phytochemical Profiling, Anti-Inflammatory, Anti-Oxidant and In-Silico Approach of Cornus macrophylla Bioss (Bark)>, Quality Control of 112-63-0, the main research area is Cornus macrophylla antiinflammatory antioxidant phytochem profiling; Cornus macrophylla; GC-MS; anti-inflammatory; antioxidant.
The objective of the current study was to evaluate the phytochem. and pharmacol. potential of the Cornus macrophylla. C. macrophylla belongs to the family Cornaceae. It is locally known as khadang and is used for the treatment of different diseases such as analgesic, tonic, diuretic, malaria, inflammation, allergy, infections, cancer, diabetes, and lipid peroxidative. The crude extract and different fractions of C. macrophyll were evaluated by gas chromatog. and mass spectroscopy (GC-MS), which identified the most potent bioactive phytochems. The antioxidant ability of C. macrophylla was studied by 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulfonic acid (ABTS) and 1,1 diphenyl-2-picryl-hydrazyl (DPPH) methods. The crude and subsequent fractions of the C. macrophylla were also tested against anti-inflammatory enzymes using COX-2 (Cyclooxygenase-2) and 5-LOX (5-lipoxygenase) assays. The mol. docking was carried out using mol. operating environment (MOE) software. The GC-MS study of C. macrophylla confirmed forty-eight compounds in Et acetate (Et.AC) fraction and revealed that the Et.AC fraction was the most active fraction. The antioxidant ability of the Et.AC fraction showed an IC50 values of 09.54μg/mL and 7.8μg/mL against ABTS and DPPH assay resp. Among all the fractions of C. macrophylla, Et.AC showed excellent activity against COX-2 and 5-LOX enzyme. The observed IC50 values were 93.35μg/mL against COX-2 and 75.64μg/mL for 5-LOX resp. Mol. docking studies supported these in vitro results and confirmed the anti-inflammatory potential of C. macrophylla. C. macrophylla has promising potential as a source for the development of new drugs against inflammation in the future.
Molecules published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.
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