Jablonowski, Jill A.; Grice, Cheryl A.; Chai, Wenying; Dvorak, Curt A.; Venable, Jennifer D.; Kwok, Annette K.; Ly, Kiev S.; Wei, Jianmei; Baker, Sherry M.; Desai, Pragyna J.; Jiang, Wen; Wilson, Sandy J.; Thurmond, Robin L.; Karlsson, Lars; Edwards, James P.; Lovenberg, Timothy W.; Carruthers, Nicholas I. published the artcile< The First Potent and Selective Non-Imidazole Human Histamine H4 Receptor Antagonists>, Quality Control of 112-63-0, the main research area is indole derivative preparation histamine H4 receptor antagonist structure activity.
Following the discovery of the human histamine H4 receptor, a high throughput screen of our corporate compound collection identified a potential lead compound Investigation of the structure-activity relationship (SAR) resulted in the discovery of novel compounds, which are the first potent and selective histamine H4 receptor antagonists to be described.
Journal of Medicinal Chemistry published new progress about Antihistamines. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.
Referemce:
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