Effenberger, Franz; Stelzer, Uwe published the artcile< Enzyme-catalyzed reactions. 15. Preparation of (R)-2-(sulfonyloxy) nitriles and their reactions with acetates. Inversion of the configuration of optically active cyanohydrins>, Synthetic Route of 112-63-0, the main research area is nitrile sulfonyloxy preparation transacylation; acetoxy nitrile preparation enzymic deacetylation; cyanohydrin configuration inversion.
(R)-R1SO3CHRCN (I, R = Pr, CH2CHMe2, CH2CH2SMe, cyclohexyl, cyclohexenyl; R1 = 4-MeC6H4, Me, CF3) were obtained in high optical purity by sulfonylation of (R)-HOCHRCN. In contrast to I, (R)-R1SO3CHPhCN (II) are unstable at higher temperature I react at room temperature with alkali acetates in a typical SN2 manner to give (S)-AcOCHRCN in high optical purity. Under these reaction conditions, II partly racemize and decompose Hydrolysis of (S)-AcOCHRCN gave (S)-I.
Chemische Berichte published new progress about Configuration. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics