Demont, Emmanuel H.; Bamborough, Paul; Chung, Chun-wa; Craggs, Peter D.; Fallon, David; Gordon, Laurie J.; Grandi, Paola; Hobbs, Clare I.; Hussain, Jameed; Jones, Emma J.; Le Gall, Armelle; Michon, Anne-Marie; Mitchell, Darren J.; Prinjha, Rab K.; Roberts, Andy D.; Sheppard, Robert J.; Watson, Robert J. published the artcile< 1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is benzimidazolone preparation bromodomain inhibitor; crystal structure; BRD1; BRPF1; BRPF2; BRPF3; bromodomain; chemical probe; epigenetics; fragment; inhibitor.
The BRPF (bromodomain and PHD finger-containing) protein family are important scaffolding proteins for assembly of MYST histone acetyltransferase complexes. Here, the authors report the discovery, binding mode, and structure-activity relationship (SAR) of the first potent, selective series of inhibitors of the BRPF1 bromodomain.
ACS Medicinal Chemistry Letters published new progress about Bromodomain-containing proteins Role: BSU (Biological Study, Unclassified), PRP (Properties), RCT (Reactant), BIOL (Biological Study), RACT (Reactant or Reagent) (crystal structure, complexes with di-Me benzimidazolones). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics