Correia, Jose Tiago M.; Acconcia, Lais V.; Coelho, Fernando published the artcile< Studies on Pumiliotoxin A Alkaloids: An Approach to Preparing the Indolizidinic Core by Intramolecular Diastereoselective N-Heterocyclic Carbene Catalyzed Benzoin Reaction>, Quality Control of 112-63-0, the main research area is pumiliotoxin A indolizidinic core preparation intramol diastereoselective benzoin; diastereoselective heterocyclic carbene catalyst benzoin reaction.
In this article, we describe the development of a convergent organocatalytic strategy to prepare the indolizidinic core I of the pumiliotoxin A alkaloid family. The key step of the proposed strategy is based on a diastereoselective N-heterocyclic carbene catalyzed benzoin reaction, in which the Breslow intermediate generated from an enal moiety in dicarbonyl compound II (umpolung a1 to d1 – acyl anion equivalent) attacks a ketone moiety intramolecularly to provide the indolizidinone core in good yield with good selectivity.
European Journal of Organic Chemistry published new progress about Benzoin condensation reaction (stereoselective). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.
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