Month: September 2022

HPLC of Formula: 4707-47-5In 2018, Seklic, Dragana S.;Obradovic, Ana D.;Stankovic, Milan S.;Zivanovic, Marko N.;Mitrovic, Tatjana Lj.;Stamenkovic, Slavisa M.;Markovic, Snezana D. published 《Proapoptotic and antimigratory effects of Pseudevernia furfuracea and Platismatia glauca on colon cancer cell lines original scientific paper》. 《Food Technology and Biotechnology》published the findings. The article contains the following contents:

The aim of this study is to investigate cytotoxic, proapoptotic, antimigratory and pro-antioxidant effects of methanol, acetone and Et acetate extracts of lichens Pseudevernia furfuracea and Platismatia glauca on colorectal cancer (HCT-116 and SW-480) cell lines. We compared the cytotoxic effects on colorectal cancer cells with the effects obtained from normal human fibroblast (MRC-5) cell line. Tetrazolium (MTT) test evaluated the cytotoxic effects, Transwell assay evaluated cell migration, acridine orange/ethidium bromide (AO/EB) fluorescent method followed the apoptosis, while prooxidant/antioxidant effects were determined spectrophotometrically through concentration of redox parameters. The tested extracts showed considerable cytotoxic effect on cancer cells with no observable cytotoxic effect on normal cells. Et acetate and acetone extract of P. furfuracea induced the highest cytotoxicity (IC50 = (21.2 ± 1.3) μg/mL on HCT-116, and IC50 = (51.3 ± 0.8) μg/mL on SW-480 cells, resp., after 72 h), with noteworthy apoptotic and prooxidant effects, and antimigratory potential of methanol extract P. glauca extracts induced cytotoxic effects on HCT-116 cells after 72 h (IC50<40μg/mL), while only methanol and acetone extracts had cytotoxic effects on SW-480 cells after 24 h, with proapoptotic/necrotic activity, as a consequence of induced oxidative stress. In conclusion, lichen extracts changed to a great extent cell viability and migratory potential of colorectal cancer cell lines. HCT-116 cells were more sensitive to treatments, P. furfuracea had better proapoptotic and antimigratory effects, and both investigated lichen species might be a source of substances with anticancer activity.Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) were involved in the experimental procedure.

Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.HPLC of Formula: 4707-47-5

Reference:
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Schulze, Julia S.;Brand, Raoul D.;Hering, Joachim G. C.;Riegger, Luise M.;Schreiner, Peter R.;Smarsly, Bernd M. published 《DMAP Immobilized on Porous Silica Particles and Monoliths for the Esterification of Phenylethanol in Continuous Flow》. The research results were published in《ChemCatChem》 in 2022.Recommanded Product: 1-Phenylethyl acetate The article conveys some information:

We report the immobilization of 4-dimethylaminopyridine (DMAP), a versatile organocatalyst for sterically demanding esterifications, on mesoporous silica particles and macro-mesoporous silica monoliths, both possessing optimized properties for continuous flow synthesis. An alkyne-functionalized DMAP derivative was immobilized via click chem.; the materials were characterized by physisorption anal., diffuse reflectance IR Fourier transform spectroscopy (DRIFT) and elemental anal. While silica particles were functionalized in batch and packed into a packed-bed reactor, monoliths were cladded with a polyether ether ketone (PEEK) tube after sol-gel synthesis and functionalized in a circulating flow process. Samples with three different catalyst loadings were prepared, in order to study the impact of the catalyst amount on the mesopore space as well as the catalytic performance. In continuous flow experiments, complete conversion of 1-phenylethanol to phenylethylacetate was achieved with both materials and short contact times. Monoliths exhibited far lower pressures than packed bed reactors (7 bar at a flow rate of 1 mL min^-1) and reached turnover rates up to 9.3 × 10^-2 s^-1, which is almost twice as high as a comparable batch experiment The absence of diffusion limitations in monoliths made investigations on reaction kinetics with microkinetics-dominated experiments possible. This study demonstrates that all properties needed for a successful transfer of immobilized organocatalysts to sophisticated flow syntheses with complex organocatalysts can be met with functionalized meso-macroporous monoliths. The experimental procedure involved many compounds, such as 1-Phenylethyl acetate (cas: 93-92-5) .

1-Phenylethyl acetate(cas:93-92-5) is a carboxylic ester. Recommanded Product: 1-Phenylethyl acetate It may be prepared by acetylation of methyl phenyl carbinol; from benzaldehyde by reacting with magnesium methyl bromide and subsequent acetylation; from 1-bromoethylbenzene and silver acetate in acetic acid.

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Product Details of 3779-29-1In 2008, Cardoso, Renata da Silva;Galvao da Silva, Micheli;Marques, Maria de Fatima Vieira published 《Evaluation of internal and external donors in the supported Ziegler-Natta catalyst for stereospecific propylene polymerization》. 《Annual Technical Conference – Society of Plastics Engineers》published the findings. The article contains the following contents:

In the present work, the effects of Bu phthalate as internal electron donor on the preparation of MgCl₂-supported Ziegler-Natta catalyst and of dimethoxy-diphenylsilane as external electron donor were evaluated in propylene polymerization and compared with the new prepared Ziegler-Natta systems employing diverse internal and external electron donors. Polymers were characterized by IR absorption spectroscopy, differential scanning calorimetry and by heptane extraction The new prepared catalysts did not achieve the same polymer yields compared with the reference catalyst. On the other hand, the catalysts with the new internal donors produced polymers with isotacticity index up to 98% in the polymerization conditions employed. The experimental procedure involved many compounds, such as Diethyl cyclobutane-1,1-dicarboxylate (cas: 3779-29-1) .

Diethyl 1,1-cyclobutanedicarboxylate(cas:3779-29-1 Product Details of 3779-29-1) reacts with silicon to form diethyl esters and magnesium to form magnesium salts. The reaction time for this compound is short, which may be due to its ability to undergo debromination.

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Ester – an overview | ScienceDirect Topics

COA of Formula: C10H16O4In 1985, Perkins, M. John;Adae-Amoakoh, Sylvia;Mitchell, John C.;Smith, Brian V. published 《Intramolecular cyclizations of primary alkyl esters of 3-bromopropylmalonic acid: an unexpected correlation between activation parameters and alkyl chain lengths》. 《Journal of Chemical Research, Synopses》published the findings. The article contains the following contents:

The cyclization rate of Br(CH₂)₃CH(CO₂R)₂ [R = Me, Et, Bu, (CH₂)₅Me] increased regularly with the chain length of R. Plots of the entropy and enthalpy of activation of the reaction vs. the chain length unexpectedly gave linear graphs of high correlation coefficient (0.98 and 0.99, resp.).Diethyl cyclobutane-1,1-dicarboxylate (cas: 3779-29-1) were involved in the experimental procedure.

Diethyl cyclobutane-1,1-dicarboxylate (cas:3779-29-1
) is a solid catalyst that can be used in the synthesis of alkylating agents. It is used in the manufacture of cyclopropyl ketones and has been shown to exhibit anticancer properties.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kekuda, T. R. Prashith;Lavanya, D.;Rao, Pooja published 《Lichens as promising resources of enzyme inhibitors: a review》 in 2019. The article was appeared in 《Journal of Drug Delivery and Therapeutics》. They have made some progress in their research.Reference of Methyl 2,4-dihydroxy-3,6-dimethylbenzoate The article mentions the following:

A review. Inhibition of some enzymes seems to be one of the therapeutic strategies for the management of certain diseases or conditions such as diabetes, Alzheimer’s disease, cancer and obesity. In this review, an updated information on the enzyme inhibitory activity of lichen extracts and lichen compounds by an intensive literature survey is presented. Crude solvent extracts and isolated compounds from lichens were shown to be effective in causing inhibition of several enzymes such as amylase, lipase, lipoxygenase, aromatase, cyclooxygenase, trypsin, β-glucoronidase, prolyl endopeptidase, monoamine oxidase, urease, tyrosinase, xanthine oxidase, Thioredoxin reductase, glucosidase, topoisomerase, pancreatic elastase, phosphodiesterase, telomerase and acetylcholinesterase. Lichen metabolites such as usnic acid and its derivatives, lobaric acid, physodic acid, ramalin, protolichestrinic acid, salazinic acid, atranorin, evernic acid, zeorin, diffractic acid, psoromic acid, Me β-orcinolcarboxylate, methylorsellinate, and anziaic acid were shown to be inhibitors of some enzymes. In conclusion, lichens can be employed as promising therapeutic agents in terms of their potential to inhibit the activity of certain enzymes that are involved in some diseases or disorders. In vitro culturing of lichen symbionts in optimized media can be carried out to isolate enzyme inhibitors in larger scale and to develop effective therapeutic agents. To complete the study, the researchers used Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) .

Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.Reference of Methyl 2,4-dihydroxy-3,6-dimethylbenzoate

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of Methyl oleate《Phosphotungstic acid and propylsulfonic acid bifunctionalized ordered mesoporous silica: A highly efficient and reusable catalysts for esterification of oleic acid》 was published in 2022. The authors were Yu, Zhengfei;Chen, Xifeng;Zhang, Yibo;Tu, Hongyu;Pan, Pen;Li, Shuai;Han, Yuxiang;Piao, Minjun;Hu, Jianglei;Shi, Fengwei;Yang, Xia, and the article was included in《Chemical Engineering Journal (Amsterdam, Netherlands)》. The author mentioned the following in the article:

In phosphotungstic acid aqueous solution, the ordered mesoporous silica mol. sieve (HPW/OMS-SO₃H) simultaneously functionalized by phosphotungstic acid (HPW) and Pr sulfonic acid groups (-pr-SO₃H) was successfully prepared via a one-pot co-condensation method. The skeleton of the materials was formed based on the simultaneous hydrolysis and co-condensation of 3-mercaptopropyltriethoxysilane (MPTES) and tetraethoxysilane (TEOS) using in situ oxidation of the thiol groups to sulfoacid groups with H₂O₂. The materials with an ordered 2D hexagonal mesoporous structure and a high sp. surface area were confirmed by the results of small-angle XRD, N₂ adsorption-desorption, and TEM. The spectroscopy of FT-IR, UV-Vis DRS, XPS, and Raman indicated that the active component of HPW and propylsulfonic acid groups successfully immobilized on the OMS support and a strong interaction existed among silicon hydroxyl and propylsulfonic acid groups with HPW. The esterification reaction of oleic acid with methanol to produce biodiesel over prepared catalyst showed excellent catalytic activity due to the synergistic effect between the HPW and propylsulfonic acid groups. The biodiesel yield of 95.3% was obtained by 0.3HPW/OMS-SO₃H-5 catalyst under the optimum reaction conditions. The catalytic performance was not reduced significantly even after five cycles reused, because the strong interaction prevented acid-active component loss from the support. The activation energy of the reaction by the 0.3HPW/OMS-SO₃H-5 materials was investigated, which obeyed the first-order kinetics.Methyl oleate (cas: 112-62-9) were involved in the experimental procedure.

Methyl oleate(cas: 112-62-9) is a fatty acid methyl ester resulting from the formal condensation of the carboxy group of oleic acid with methanol.Reference of Methyl oleate It is also used in biochemical research as a chromatographic reference standard.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gimenez-Banon, Maria Jose;Moreno-Olivares, Juan Daniel;Paladines-Quezada, Diego Fernando;Bleda-Sanchez, Juan Antonio;Fernandez-Fernandez, Jose Ignacio;Parra-Torrejon, Belen;Delgado-Lopez, Jose Manuel;Gil-Munoz, Rocio published 《Effects of Methyl Jasmonate and Nano-Methyl Jasmonate Treatments on Monastrell Wine Volatile Composition》. The research results were published in《Molecules》 in 2022.Reference of Ethyl tetradecanoate The article conveys some information:

The application of Me jasmonate (MeJ) as an elicitor to enhance secondary metabolites in grapes and wines has been studied, but there is little information about its use in conjunction with nanotechnol. and no information about its effects on wine volatile compounds This led us to study the impact of nanoparticles doped with MeJ (Nano-MeJ, 1mM MeJ) on the volatile composition of Monastrell wines over three seasons, compared with the application of MeJ in a conventional way (10 mM MeJ). The results showed how both treatments enhanced fruity esters in wines regardless of the vintage year, although the increase was more evident when grapes were less ripe. These treatments also achieved these results in 2019 in the cases of 1-propanol, beta-phenyl-ethanol, and methionol, in 2020 in the cases of hexanol and methionol, and in 2021, but only in the case of hexanol. On the other hand, MeJ treatment also increased the terpene fraction, whereas Nano-MeJ, at the applied concentration, did not increase it in any of the seasons. In summary, although not all families of volatile compounds were increased by Nano-MeJ, the Nano-MeJ treatment generally increased the volatile composition to an extent similar to that obtained with MeJ used in a conventional way, but at a 10 times lower dose. Therefore, the use of nanotechnol. could be a good option for improving the quality of wines from an aromatic point of view, while reducing the necessary dosage of agrochems., in line with more sustainable agricultural practices. To complete the study, the researchers used Ethyl tetradecanoate (cas: 124-06-1) .

Ethyl tetradecanoate(cas: 124-06-1) is a labeled component from essential oil of natural hawthorn perfume. Also frequently used in cosmetics, soaps, and flavorings.Reference of Ethyl tetradecanoateEthyl myristate is a long-chain fatty acid ethyl ester resulting from the formal condensation of the carboxy group of myristic acid with the hydroxy group of ethanol.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dave, Alpa Y.;Parmar, Kokila A.;Begari, Eeshwaraiah;Joshi, Deepkumar S. published 《Synthesis and biological evaluation of oxadiazole clubbed thiadiazole derivatives as antimicrobial agents》. The research results were published in《Indian Journal of Heterocyclic Chemistry》 in 2021.Application of 99-36-5 The article conveys some information:

A series of 1,3,4-oxadiazole clubbed 1,3,4-thiadiazole derivatives I [R¹ = H, 3-Me, 2-Cl, etc; R² = H, 3-Me, 4-HO, 2-Cl, 4-Cl] were synthesized and assessed in-vitro for their activity as antimicrobial agents. The target compounds I were synthesized using a basic condensation reaction between 5-(substituted phenyl)-1,3,4-oxadiazole-2-thiols and 2-chloro-N-(5-(substituted phenyl)-1,3,4-thiadiazol-2-yl)acetamides in presence of K₂CO₃ as a scavenging agent and acetone as reaction solvent. The compounds I synthesized here, exhibited excellent to moderate antimicrobial activity against a broad panel of antibacterial strains of Gram-pos. and Gram-neg. bacteria and fungi.Methyl 3-methylbenzoate (cas: 99-36-5) were involved in the experimental procedure.

Methyl 3-methylbenzoate (cas: 99-36-5) is a common ester.Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids.Application of 99-36-5 Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Product Details of 124-06-1In 2022, Ali, Barkat;Khan, Kiran Yasmin;Majeed, Hamid;Jin, Yamei;Xu, Dan;Rao, Zhiming;Xu, Xueming published 《Impact of Soy-Cow’s mixed milk enzyme modified cheese on bread aroma》. 《LWT–Food Science and Technology》published the findings. The article contains the following contents:

The effect of spray-dried Soy-Cow’s mixed milk enzyme modified (SC-EM) cheese on wheat dough properties and bread aroma was evaluated at either 0.1, 0.5, 1.0, 1.5 or 2.0% (weight/weight). Significant accumulation of amino acids and peptides of dough were noted as SC-EM cheese levels increased. After baking a total of 118 volatile compounds (VCs) were identified in breads having aldehydes, alcs., esters and acids in major proportions. Higher contents of Maillard product 3-hydroxy-2-butanone, 2-methyl-1-propanol, phenylethyl alc., undecane, L-limonene, 2-pentyl furan and lipid oxidation compounds hexanoic acid Et ester, octanoic acid Et ester, decanoic acid Et ester, butanoic acid, hexanoic acid and octanoic acid were observed Isoamyl alc., lactic acid Et ester, Et sorbate and sorbic acid were the newly identified VCs. These results revealed that SC-EM cheese could be used as improver in dough and contribution to bread aroma. Thus, SC-EM cheese has been proposed to be included in fortified bakery products.Ethyl tetradecanoate (cas: 124-06-1) were involved in the experimental procedure.

Ethyl tetradecanoate(cas: 124-06-1) is a natural product found in Psidium guajava, Litchi chinensis, and other organisms.Product Details of 124-06-1Ethyl myristate is a long-chain fatty acid ethyl ester resulting from the formal condensation of the carboxy group of myristic acid with the hydroxy group of ethanol.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xiang, Ming;Zhou, Chao;Yang, Xiu-Long;Chen, Bin;Tung, Chen-Ho;Wu, Li-Zhu published 《Visible Light-Catalyzed Benzylic C-H Bond Chlorination by a Combination of Organic Dye (Acr⁺-Mes) and N-Chlorosuccinimide》 in 2020. The article was appeared in 《Journal of Organic Chemistry》. They have made some progress in their research.Formula: C9H10O2 The article mentions the following:

By combining “N-chlorosuccinimide (NCS)” as the safe chlorine source with “Acr⁺-Mes” as the photocatalyst, we successfully achieved benzylic C-H bond chlorination under visible light irradiation Furthermore, benzylic chlorides could be converted to benzylic ethers smoothly in a one-pot manner by adding sodium methoxide. This mild and scalable chlorination method worked effectively for diverse toluene derivatives, especially for electron-deficient substrates. Careful mechanistic studies supported that NCS provided a hydrogen abstractor “N-centered succinimidyl radical,” which was responsible for the cleavage of the benzylic C-H bond, relying on the reducing ability of Acr^•-Mes.Methyl 3-methylbenzoate (cas: 99-36-5) were involved in the experimental procedure.

Methyl 3-methylbenzoate (cas: 99-36-5) is a common ester.Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids.Formula: C9H10O2 Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics