Month: September 2022

Ester is a chemical compound derived from an oxoacid (organic or inorganic) in which at least one –OH hydroxyl group is replaced by an –O– alkyl (alkoxy) group, 99769-19-4, formula is C8H9BO4, Name is 3-(Methoxycarbonyl)phenylboronic acid. as in the substitution reaction of a carboxylic acid and an alcohol. Related Products of 99769-19-4.

Hu, Huayou;Chen, Si-Jie;Mandal, Mukunda;Pratik, Saied Md;Buss, Joshua A.;Krska, Shane W.;Cramer, Christopher J.;Stahl, Shannon S. research published 《 Copper-catalyzed benzylic C-H coupling with alcohols via radical relay enabled by redox buffering》, the research content is summarized as follows. Copper-catalyzed oxidative cross-coupling of benzylic C-H bonds with alcs. to afford benzyl ethers, enabled by a redox buffering strategy that maintains the activity of the copper catalyst throughout the reaction was reported. The reactions employ the C-H substrate as the limiting reagent and exhibit broad scope with respect to both coupling partners. This approach to direct site-selective functionalization of C(sp³)-H bonds provides the basis for efficient three-dimensional diversification of organic mols. and should find widespread utility in organic synthesis, particularly for medicinal chem. applications.

Related Products of 99769-19-4, 3-Methoxycarbonylphenylboronic acid is a useful research compound. Its molecular formula is C8H9BO4 and its molecular weight is 179.97 g/mol. The purity is usually 95%.

3-Methoxycarbonylphenylboronic acid is a reactanct that has been involved in a variety of applications. For instance, it has been used in Suzuki-Miyaura cross-coupling, Iterative cross-coupling of boronate building blocks, cross-coupling with aryl/ alkenyl sulfonates, synthesis of symmetrical biaryls via CuCl catalyzed homocoupling, trifluoromethylation, and cyanation just to name a few of its many uses.

3-Methoxycarbonylphenylboronic acid is a boronate ligand that has been shown to have an interaction with the nitrogen atoms in amines. This compound is used for the Suzuki coupling reaction, which is a chemical reaction between an organoboron compound and an organic electrophile. 3-Methoxycarbonylphenylboronic acid has a helical structure that can be seen by FTIR spectroscopy and it has potent inhibitory activity., 99769-19-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Polyesters are important plastics, with monomers linked by ester moieties. Phosphoesters form the backbone of DNA molecules. 99769-19-4, formula is C8H9BO4, Name is 3-(Methoxycarbonyl)phenylboronic acid.Nitrate esters, such as nitroglycerin, are known for their explosive properties. Recommanded Product: 3-(Methoxycarbonyl)phenylboronic acid.

Hrast, Martina;Frlan, Rok;Knez, Damijan;Zdovc, Irena;Barreteau, Helene;Gobec, Stanislav research published 《 Mur ligases inhibitors with azastilbene scaffold: Expanding the structure-activity relationship》, the research content is summarized as follows. Antibiotic resistance represents one of the biggest public health challenges in the last few years. Mur ligases (MurC-MurF) are involved in the synthesis of UDP-N-acetylmuramyl-pentapeptide, the main building block of bacterial peptidoglycan polymer. They are essential for the survival of bacteria and therefore important antibacterial targets. We report herein the synthesis and structure-activity relationships of Mur ligases inhibitors with an azastilbene scaffold. Several compounds, e.g., I, showed promising inhibitory potencies against multiple ligases and one compound also possessed moderate antibacterial activity. These results represent a solid ground for further development and optimization of structurally novel antimicrobial agents to combat the rising bacterial resistance.

99769-19-4, 3-Methoxycarbonylphenylboronic acid is a useful research compound. Its molecular formula is C8H9BO4 and its molecular weight is 179.97 g/mol. The purity is usually 95%.

3-Methoxycarbonylphenylboronic acid is a reactanct that has been involved in a variety of applications. For instance, it has been used in Suzuki-Miyaura cross-coupling, Iterative cross-coupling of boronate building blocks, cross-coupling with aryl/ alkenyl sulfonates, synthesis of symmetrical biaryls via CuCl catalyzed homocoupling, trifluoromethylation, and cyanation just to name a few of its many uses.

3-Methoxycarbonylphenylboronic acid is a boronate ligand that has been shown to have an interaction with the nitrogen atoms in amines. This compound is used for the Suzuki coupling reaction, which is a chemical reaction between an organoboron compound and an organic electrophile. 3-Methoxycarbonylphenylboronic acid has a helical structure that can be seen by FTIR spectroscopy and it has potent inhibitory activity., Recommanded Product: 3-(Methoxycarbonyl)phenylboronic acid

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 2495-37-6, formula is C11H12O2, Name is Benzyl methacrylate. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Safety of Benzyl methacrylate.

Hou, Wangmeng;Li, Zheqi;Xu, Lu;Li, Yuanchao;Shi, Yi;Chen, Yongming research published 《 High-Yield Synthesis of Molecular Bottlebrushes via PISA-Assisted Grafting-from Strategy》, the research content is summarized as follows. To prepare mol. bottlebrushes with high yield via a grafting-from strategy using a reversible deactivation radical polymerization (RDRP) technique has always been a big challenge due to the intra- and intermol. radical-radical coupling. Herein, a polymerization-induced self-assembly (PISA)-assisted grafting-from strategy based on reversible addition-fragmentation chain transfer (RAFT) dispersion polymerization was developed to synthesize the Janus mol. bottlebrushes with a well-defined structure and high yield using polynorbornene-g-(poly(ethylene glycols)-branch-RAFT agent) (PNB-g-(PEG-branch-CTA)) as a solvophilic multifunctional macro-CTA. The results indicated the biradical coupling terminations of propagating side chains could be significantly suppressed due to the nanoconfinement effect in the PISA of the generated Janus mol. bottlebrushes. Janus mol. bottlebrushes with a narrow mol. weight distribution (M_w/M_n < 1.25) and negligible intermol. crosslinking at monomer conversion as high as 84% were prepared, demonstrating the efficiency and versatility of the PISA-assisted grafting-from approach.

Safety of Benzyl methacrylate, Benzyl methacrylate, also known as Benzyl methacrylate, is a useful research compound. Its molecular formula is C11H12O2 and its molecular weight is 176.21 g/mol. The purity is usually 95%.
Benzyl methacrylate is a chemical compound that belongs to the group of benzyl compounds. It has a copolymer structure with methyl ethyl methacrylate (MEMA) and hydroxyl groups. Benzyl methacrylate is produced by polymerization of benzyl chloride with allyl carbonate in the presence of radiation, forming a polymeric matrix. The morphology of this copolymer depends on the length of the benzyl chains and the concentration of MEMA., 2495-37-6.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 2495-37-6, formula is C11H12O2, Name is Benzyl methacrylate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Quality Control of 2495-37-6.

Honciuc, Andrei;Negru, Oana-Iuliana research published 《 Role of Surface Energy of Nanoparticle Stabilizers in the Synthesis of Microspheres via Pickering Emulsion Polymerization》, the research content is summarized as follows. Polymer microspheres are important for a variety of applications, such as ion exchange chromatog., catalyst supports, absorbents, etc. Synthesis of large microspheres can be challenging, because they cannot be obtained easily via classic emulsion polymerization, but rather by more complex methods. Here, we present a facile method for obtaining polymer microspheres, beyond 50μm, via Pickering emulsion polymerization The method consists in creating oil-in-water (o/w) Pickering emulsion/suspension from vinyl bearing monomers, immiscible with water, whereas silica nanoparticles (NPs), bearing glycidyl functionalities, have a stabilizing role by adsorbing at the monomer/water interface of emulsion droplets. The emulsion is polymerized under UV light, and polymer microspheres decorated with NPs are obtained. We discovered that the contact angle of the NPs with the polymer microsphere is the key parameter for tuning the size and the quality of the obtained microspheres. The contact angle depends on the NPs’ interfacial energy and its polar and dispersive contributions, which we determine with a newly developed NanoTraPPED method. By varying the NPs’ surface functionality, we demonstrate that when their interfacial energy with water decreases, their energy of adhesion to water increases, causing the curvature of the polymer/water interface to decrease, resulting in increasingly larger polymer microspheres.

Quality Control of 2495-37-6, Benzyl methacrylate, also known as Benzyl methacrylate, is a useful research compound. Its molecular formula is C11H12O2 and its molecular weight is 176.21 g/mol. The purity is usually 95%.
Benzyl methacrylate is a chemical compound that belongs to the group of benzyl compounds. It has a copolymer structure with methyl ethyl methacrylate (MEMA) and hydroxyl groups. Benzyl methacrylate is produced by polymerization of benzyl chloride with allyl carbonate in the presence of radiation, forming a polymeric matrix. The morphology of this copolymer depends on the length of the benzyl chains and the concentration of MEMA., 2495-37-6.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Polyesters are important plastics, with monomers linked by ester moieties. Phosphoesters form the backbone of DNA molecules. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate.Nitrate esters, such as nitroglycerin, are known for their explosive properties. Safety of Diethyl 2-(ethoxymethylene)malonate.

Holt-Martyn, James P.;Chowdhury, Rasheduzzaman;Tumber, Anthony;Yeh, Tzu-Lan;Abboud, Martine I.;Lippl, Kerstin;Lohans, Christopher T.;Langley, Gareth W.;Figg, William Jr.;McDonough, Michael A.;Pugh, Christopher W.;Ratcliffe, Peter J.;Schofield, Christopher J. research published 《 Structure-Activity Relationship and Crystallographic Studies on 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors》, the research content is summarized as follows. The 2-oxoglutarate-dependent hypoxia inducible factor prolyl hydroxylases (PHDs) are targets for treatment of a variety of diseases including anemia. One PHD inhibitor is approved for use for the treatment of renal anemia and others are in late stage clin. trials. The number of reported templates for PHD inhibition is limited. We report structure-activity relationship and crystallog. studies on a promising class of 4-hydroxypyrimidine-containing PHD inhibitors.

87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., Safety of Diethyl 2-(ethoxymethylene)malonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Polyesters are important plastics, with monomers linked by ester moieties. Phosphoesters form the backbone of DNA molecules. 2495-37-6, formula is C11H12O2, Name is Benzyl methacrylate.Nitrate esters, such as nitroglycerin, are known for their explosive properties. Quality Control of 2495-37-6.

Hirano, Tomohiro;Kamiike, Ryota;Yuki, Takumi;Matsumoto, Daishi;Ute, Koichi research published 《 Determination of monomer reactivity ratios from a single sample using multivariate analysis of the ¹H NMR spectra of poly[(methyl methacrylate)-co-(benzyl methacrylate)]》, the research content is summarized as follows. Copolymers of Me methacrylate (MMA) and benzyl methacrylate (BnMA) were prepared by conventional radical copolymerization in toluene at 70°C. The ¹H NMR (NMR) spectra of these copolymers were measured in various solvents at different temperatures The signals of the methoxy protons in the MMA units and the benzyl protons in the BnMA units showed splitting mainly because of the triad monomer sequences when the temperature was increased to 150°C in deuterated DMSO. However, the splitting was not sufficient to determine the molar ratios of the triad sequences. Therefore, multivariate anal. was applied to the ¹H NMR spectra of copolymers with various chem. compositions Principal component anal. successfully extracted information on the polymer microstructures. Partial least-squares (PLS) regression successfully predicted the mole fractions of the diad monomer sequences. Then, the fractions of the diad sequences in an unknown sample prepared in benzene at 60°C were predicted using PLS regression to determine the monomer reactivity ratios. Thus, the monomer reactivity ratios were successfully determined from a single sample using multivariate anal. of the ¹H NMR spectra of copolymers of MMA and BnMA.

Quality Control of 2495-37-6, Benzyl methacrylate, also known as Benzyl methacrylate, is a useful research compound. Its molecular formula is C11H12O2 and its molecular weight is 176.21 g/mol. The purity is usually 95%.
Benzyl methacrylate is a chemical compound that belongs to the group of benzyl compounds. It has a copolymer structure with methyl ethyl methacrylate (MEMA) and hydroxyl groups. Benzyl methacrylate is produced by polymerization of benzyl chloride with allyl carbonate in the presence of radiation, forming a polymeric matrix. The morphology of this copolymer depends on the length of the benzyl chains and the concentration of MEMA., 2495-37-6.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 870-50-8, formula is C10H18N2O4, Name is Di-tert-butyl diazene-1,2-dicarboxylate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. HPLC of Formula: 870-50-8.

Hill, Matthew D.;Fang, Haiquan;Norris, Derek;Delucca, George V.;Huang, Hong;DeBenedetto, Mikkel;Quesnelle, Claude;Schmitz, William D.;Tokarski, John S.;Sheriff, Steven;Yan, Chunhong;Fanslau, Caroline;Haarhoff, Zuzana;Huang, Christine;Kramer, Melissa;Madari, Shilpa;Menard, Krista;Monereau, Laura;Morrison, John;Raghavan, Nirmala;Shields, Eric E.;Simmermacher-Mayer, Jean;Sinz, Michael;Tye, Ching Kim;Westhouse, Richard;Xie, Chunshan;Zhang, Haiying;Zhang, Lisa;Zvyaga, Tatyana;Lee, Francis;Gavai, Ashvinikumar V.;Degnan, Andrew P. research published 《 Development of BET Inhibitors as Potential Treatments for Cancer: Optimization of Pharmacokinetic Properties》, the research content is summarized as follows. We describe the synthesis of triazole-containing carboline derivatives and their utility as bromodomain and extra-terminal (BET) inhibitors. A convergent synthetic route permitted the detailed investigation of deuteration and fluorination strategies to reduce clearance while maintaining a favorable in vitro profile. This work led to the identification of a potent BET inhibitor, 2-{8-fluoro-3-[4-(²H₃)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-5-[(S)-(oxan-4-yl)(phenyl)methyl]-5H-pyrido[3,2-b]indol-7-yl}propan-2-ol (15), which demonstrated reduced clearance and an improved pharmacokinetic (PK) profile across preclin. species. Importantly, no major metabolite was observed when 15 was incubated with human hepatocytes (hHEP) for 2 h. This study culminated with the evaluation of 15 in a mouse triple-neg. breast cancer (TNBC) tumor model where it demonstrated robust efficacy at low doses.

HPLC of Formula: 870-50-8, Di-tert-butyl azodicarboxylate, also known as Di-tert-butyl azodicarboxylate, is a useful research compound. Its molecular formula is C₁₀H₁₈N₂O₄ and its molecular weight is 230.26 g/mol. The purity is usually 95%.
Di-tert-butyl azodicarboxylate is a reagent used in the electrophilic amination of β-keto esters catalyzed by an axially chiral guanidine. Building block in an enantioselective synthesis of 3,6-dihyropyridazines employing organocatalysts such a L-proline or (S)-2-pyrrolidinyl tetrazole. Utilized in the asymmetric Friedel-Crafts amination via a chiral organocatalyst.
Di-tert-butyl azodicarboxylate is a reagent used in the preparation of acyl hydrazinedicarboxylates via photoorganocatalytic hydroacylation of dialkyl azodicarboxylates with aldehydes in presence of phenylglyoxylic acid as photocatalyst., 870-50-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 870-50-8, formula is C10H18N2O4, Name is Di-tert-butyl diazene-1,2-dicarboxylate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Quality Control of 870-50-8.

Herbort, James H.;Bednar, Taylor N.;Chen, Andrew D.;RajanBabu, T. V.;Nagib, David A. research published 《 γ C-H Functionalization of Amines via Triple H-Atom Transfer of a Vinyl Sulfonyl Radical Chaperone》, the research content is summarized as follows. A selective, remote desaturation has been developed to rapidly access homoallyl amines from their aliphatic precursors. The strategy employs a triple H-atom transfer (HAT) cascade, entailing (i) cobalt-catalyzed metal-HAT (MHAT), (ii) carbon-to-carbon 1,6-HAT, and (iii) Co-H regeneration via MHAT. A new class of sulfonyl radical chaperone (to rapidly access and direct remote, radical reactivity) enables remote desaturation of diverse amines, amino acids, and peptides with excellent site-, chemo-, and regioselectivity. The key, enabling C-to-C HAT step in this cascade was computationally designed to satisfy both thermodn. (bond strength) and kinetic (polarity) requirements, and it has been probed via regioselectivity, isomerization, and competition experiments We have also interrupted this radical transfer dehydrogenation to achieve γ-selective C-Cl, C-CN, and C-N bond formations.

870-50-8, Di-tert-butyl azodicarboxylate, also known as Di-tert-butyl azodicarboxylate, is a useful research compound. Its molecular formula is C₁₀H₁₈N₂O₄ and its molecular weight is 230.26 g/mol. The purity is usually 95%.
Di-tert-butyl azodicarboxylate is a reagent used in the electrophilic amination of β-keto esters catalyzed by an axially chiral guanidine. Building block in an enantioselective synthesis of 3,6-dihyropyridazines employing organocatalysts such a L-proline or (S)-2-pyrrolidinyl tetrazole. Utilized in the asymmetric Friedel-Crafts amination via a chiral organocatalyst.
Di-tert-butyl azodicarboxylate is a reagent used in the preparation of acyl hydrazinedicarboxylates via photoorganocatalytic hydroacylation of dialkyl azodicarboxylates with aldehydes in presence of phenylglyoxylic acid as photocatalyst., Quality Control of 870-50-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 2495-37-6, formula is C11H12O2, Name is Benzyl methacrylate. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Application In Synthesis of 2495-37-6.

Herbort, James H.;Lalisse, Remy F.;Hadad, Christopher M.;RajanBabu, T. V. research published 《 Cationic Co(I) Catalysts for Regiodivergent Hydroalkenylation of 1,6-Enynes: An Uncommon cis-α-C-H Activation Leads to Z-Selective Coupling of Acrylates》, the research content is summarized as follows. Two intermol. hydroalkenylation reactions of 1,6-enynes N(R)(CH²CH=CH²)CH²CCR¹ (R = -N(Ts)-, -C(COOEt)₂-, -O-, -N(Boc)-; R¹ = 4-fluorophenyl, thiophen-3-yl, prop-1-en-2-yl, etc.) are presented which yield substituted 5-membered carbo- and -heterocycles I (R = -N(Ts)-, -C(COOEt)²-; R² = H, Me; R³ = H, Me, n-Bu). This reactivity is enabled by a cationic bis-diphenylphosphinopropane (DPPP)CoI species which forms a cobaltacyclopentene intermediate by oxidative cyclization of the enyne. This key species interacts with alkenes in distinct fashion, depending on the identity of the coupling partner to give regiodivergent products I. Simple alkenes undergo insertion reactions to furnish 1,3-dienes whereby one of the alkenes is tetrasubstituted. The acerylates R⁴CH=C(R⁵)C(O)OR⁶ (R⁴ = H, Me, OMe; R⁵ = H, Me; R⁶ = Me, Bn, Cy, t-Bu) were employed as coupling partners, and the site of intermol. C-C formation shifts from the alkyne to the alkene motif of the enyne, yielding Z-substituted-acrylate derivatives II. Computational studies provide support for the exptl. observations and show that the turnover-limiting steps in both reactions are the interactions of the alkenes with the cobaltacyclopentene intermediate via either a 1,2-insertion in the case of ethylene, or an unexpected α-C-H activation in the case of most acrylates. Thus, the H syn to the ester is activated through the coordination of the acrylate carbonyl to the cobaltacycle intermediate, which explains the uncommon Z-selectivity and regiodivergence. Variable time normalization anal. (VTNA) of the kinetic data reveals a dependence upon the concentration of cobalt, acrylate, and activator. A KIE of 2.1 was observed with Me methacrylate in sep. flask experiments, indicating that C-H cleavage is the turnover-limiting step in the catalytic cycle. Lastly, a Hammett study of aryl-substituted enynes yields a ρ value of -0.4, indicating that more electron-rich substituents accelerate the rate of the reaction.

2495-37-6, Benzyl methacrylate, also known as Benzyl methacrylate, is a useful research compound. Its molecular formula is C11H12O2 and its molecular weight is 176.21 g/mol. The purity is usually 95%.
Benzyl methacrylate is a chemical compound that belongs to the group of benzyl compounds. It has a copolymer structure with methyl ethyl methacrylate (MEMA) and hydroxyl groups. Benzyl methacrylate is produced by polymerization of benzyl chloride with allyl carbonate in the presence of radiation, forming a polymeric matrix. The morphology of this copolymer depends on the length of the benzyl chains and the concentration of MEMA., Application In Synthesis of 2495-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 99769-19-4, formula is C8H9BO4, Name is 3-(Methoxycarbonyl)phenylboronic acid. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Recommanded Product: 3-(Methoxycarbonyl)phenylboronic acid.

He, Zhangxu;Jiao, Haomiao;An, Qi;Zhang, Xin;Dan, Zengyangzong;Xu, Jiale;Liu, Hongmin;Ma, Liying;Zhao, Wen research published 《 Discovery of novel 4-phenylquinazoline-based BRD4 inhibitors for cardiac fibrosis》, the research content is summarized as follows. Bromodomain containing protein 4 (BRD4), as an epigenetic reader, can specifically bind to the acetyl lysine residues of histones and has emerged as an attractive therapeutic target for various diseases, including cancer, cardiac remodeling and heart failure. Herein, we described the discovery of hit 5 bearing 4-phenylquinazoline skeleton through a high-throughput virtual screen using 2,003,400 compound library (enamine). Then, structure-activity relationship (SAR) study was performed and 47 new 4-phenylquinazoline derivatives toward BRD4 were further designed, synthesized and evaluated, using HTRF assay set up in our laboratory Eventually, we identified compound C-34, which possessed better pharmacokinetic and physicochem. properties as well as lower cytotoxicity against NRCF and NRCM cells, compared to the pos. control JQ1. Using computer-based mol. docking and cellular thermal shift assay, we further verified that C-34 could target BRD4 at mol. and cellular levels. Furthermore, treatment with C-34 effectively alleviated fibroblast activation in vitro and cardiac fibrosis in vivo, which was correlated with the decreased expression of BRD4 downstream target c-MYC as well as the depressed TGF-β1/Smad2/3 signaling pathway. Taken together, our findings indicate that novel BRD4 inhibitor C-34 tethering a 4-phenylquinazoline scaffold can serve as a lead compound for further development to treat fibrotic cardiovascular disease.

Recommanded Product: 3-(Methoxycarbonyl)phenylboronic acid, 3-Methoxycarbonylphenylboronic acid is a useful research compound. Its molecular formula is C8H9BO4 and its molecular weight is 179.97 g/mol. The purity is usually 95%.

3-Methoxycarbonylphenylboronic acid is a reactanct that has been involved in a variety of applications. For instance, it has been used in Suzuki-Miyaura cross-coupling, Iterative cross-coupling of boronate building blocks, cross-coupling with aryl/ alkenyl sulfonates, synthesis of symmetrical biaryls via CuCl catalyzed homocoupling, trifluoromethylation, and cyanation just to name a few of its many uses.

3-Methoxycarbonylphenylboronic acid is a boronate ligand that has been shown to have an interaction with the nitrogen atoms in amines. This compound is used for the Suzuki coupling reaction, which is a chemical reaction between an organoboron compound and an organic electrophile. 3-Methoxycarbonylphenylboronic acid has a helical structure that can be seen by FTIR spectroscopy and it has potent inhibitory activity., 99769-19-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics