Polyesters are important plastics, with monomers linked by ester moieties. Phosphoesters form the backbone of DNA molecules. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate.Nitrate esters, such as nitroglycerin, are known for their explosive properties. Safety of Diethyl 2-(ethoxymethylene)malonate.
Holt-Martyn, James P.;Chowdhury, Rasheduzzaman;Tumber, Anthony;Yeh, Tzu-Lan;Abboud, Martine I.;Lippl, Kerstin;Lohans, Christopher T.;Langley, Gareth W.;Figg, William Jr.;McDonough, Michael A.;Pugh, Christopher W.;Ratcliffe, Peter J.;Schofield, Christopher J. research published 《 Structure-Activity Relationship and Crystallographic Studies on 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors》, the research content is summarized as follows. The 2-oxoglutarate-dependent hypoxia inducible factor prolyl hydroxylases (PHDs) are targets for treatment of a variety of diseases including anemia. One PHD inhibitor is approved for use for the treatment of renal anemia and others are in late stage clin. trials. The number of reported templates for PHD inhibition is limited. We report structure-activity relationship and crystallog. studies on a promising class of 4-hydroxypyrimidine-containing PHD inhibitors.
87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.
Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., Safety of Diethyl 2-(ethoxymethylene)malonate
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