Ester is a chemical compound derived from an oxoacid (organic or inorganic) in which at least one –OH hydroxyl group is replaced by an –O– alkyl (alkoxy) group, 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. as in the substitution reaction of a carboxylic acid and an alcohol. Name: Diethyl 2-(ethoxymethylene)malonate.
Forezi, Luana da S. M.;Ribeiro, Mariana M. J.;Marttorelli, Andressa;Abrantes, Juliana L.;Rodrigues, Carlos R.;Castro, Helena Carla;Souza, Thiago Moreno L.;Boechat, Fernanda da C. S.;de Souza, Alessandra M. T.;de Souza, Maria Cecilia B. V. research published 《 Design, synthesis, in vitro and in silico studies of novel 4-oxoquinoline ribonucleoside derivatives as HIV-1 reverse transcriptase inhibitors》, the research content is summarized as follows. Human immunodeficiency virus type 1 (HIV-1) is a public health problem that affects over 38 million people worldwide. Although there are highly active antiretroviral therapies, emergence of antiviral resistant strains is a problem which leads to almost a million death annually. Thus, the development of new drugs is necessary. The viral enzyme reverse transcriptase (RT) represents a validated therapeutic target. Because the oxoquinoline scaffold has substantial biol. activities, including antiretroviral, a new series of 4-oxoquinoline ribonucleoside derivatives obtained by mol. hybridization were studied here. All synthesized compounds, e.g. I (R = H, Me), were tested against human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT), and I (R = H, Me) displayed the highest antiviral activities, with IC50 values of 1.4 and 1.6μM, resp. These compounds were less cytotoxic than AZT and showed CC50 values of 1486 and 1394μM, resp. Mol. docking studies showed that the most active compounds bound to the allosteric site of the enzyme, suggesting a low susceptibility to the development of antiviral resistance. In silico pharmacokinetic and toxicol. evaluations reinforced the potential of the active compounds as anti-HIV candidates for further exploration. Overall, this work showed that I (R = H, Me) are promising scaffold for future anti-HIV-1 RT drug design.
Name: Diethyl 2-(ethoxymethylene)malonate, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.
Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics