Month: April 2022

SDS of cas: 415918-91-1. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine, is researched, Molecular C36H30NO2P, CAS is 415918-91-1, about (R)-2,2′-Binaphthoyl-(S,S)-di(1-phenylethyl) aminophosphine. Scalable protocols for the syntheses of phosphoramidite (Feringa) ligands.

Axial-chiral nonracemic 1,1-binaphthalene-2,2′-diyl N,N-dialkylphosphoramidites I [R1, R2 = CHMePh, iPr, PhCH2, 1-(1-naphthyl)ethyl, 1-naphthylmethyl, Me] were prepared by a two-step procedure, comprising heterocyclization of PCl3 with (1R)- or (1S)-2,2′-binaphthols to give the intermediate phosphorochloridites, followed by reaction with chiral amines HNR1R2. Thus, (1R)-(-)-1,1′-binaphthalene-2,2′-diyl phosphorochloridite (1) was prepared from (1R)-(+)-1,1′-bi(2-naphthol) and 9.6 equiv of PCl3 with quant. yield; reaction of 1 with (-)-[(1S)-MePhCH]2NH gave the ligand (Rax,S,S)-I [3, R1 = R2 = (1S)-MePhCH] with 86% yield.

Although many compounds look similar to this compound(415918-91-1)SDS of cas: 415918-91-1, numerous studies have shown that this compound(SMILES:C[C@@H](N(P1OC2=CC=C3C=CC=CC3=C2C4=C5C=CC=CC5=CC=C4O1)[C@@H](C6=CC=CC=C6)C)C7=CC=CC=C7), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (R)-5-Benzyl-2,2,3-trimethylimidazolidin-4-one hydrochloride( cas:323196-43-6 ) is researched.Product Details of 323196-43-6.Burley, Jonathan C.; Gilmour, Ryan; Prior, Timothy J.; Day, Graeme M. published the article 《Structural diversity in imidazolidinone organocatalysts: a synchrotron and computational study》 about this compound( cas:323196-43-6 ) in Acta Crystallographica, Section C: Crystal Structure Communications. Keywords: structural diversity imidazolidinone organocatalyst; crystal structure methylaminocarbonyl phenylpropanaminium benzyltrimethyloxoimidazolidinium chloride; mol structure methylaminocarbonyl phenylpropanaminium benzyltrimethyloxoimidazolidinium chloride. Let’s learn more about this compound (cas:323196-43-6).

(S)-1-(Methylaminocarbonyl)-3-phenylpropanaminium chloride (S2·HCl), C10H15N2O+·Cl-, crystallizes in the orthorhombic space group P212121 with a single formula unit per asym. unit. (5R/S)-5-Benzyl-2,2,3-trimethyl-4-oxoimidazolidin-1-ium chloride (R3 and S3), C13H19N2O+·Cl-, crystallize in the same space group as S2·HCl but contain three symmetry-independent formula units. (R/S)-5-Benzyl-2,2,3-trimethyl-4-oxoimidazolidin-1-ium chloride monohydrate (R4 and S4), C13H19N2O+·Cl-·H2O, crystallize in the space group P21 with a single formula unit per asym. unit. Calculations at the B3LYP/6-31G(d,p) and B3LYP/6-311G(d,p) levels of the conformational energies of the cation in R3, S3, R4, and S4 indicate that the ideal gas-phase global energy min. conformation is not observed in the solid state. Rather, the effects of hydrogen-bonding and van der Waals interactions in the crystal structure cause the mols. to adopt higher-energy conformations, which correspond to local min. in the mol. potential energy surface.

Although many compounds look similar to this compound(323196-43-6)Product Details of 323196-43-6, numerous studies have shown that this compound(SMILES:O=C1N(C)C(C)(C)N[C@@H]1CC2=CC=CC=C2.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recommanded Product: (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine, is researched, Molecular C36H30NO2P, CAS is 415918-91-1, about Iridium-Catalyzed Enantioselective Allylic Substitution of Aliphatic Esters with Silyl Ketene Acetals as the Ester Enolates. Author is Jiang, Xingyu; Hartwig, John F..

An iridium-catalyzed enantioselective allylic substitution of aliphatic esters (E)-R1CH:CHCH2OC(O)Ph (R1 = Ph, 4-MeC6H4, 2-thienyl, 3-pyridyl, etc.) with silyl ketene acetals R22C:C(OR3)SiMe3 [R2 = Me, Et; R22 = (CH2)3, (CH2)5, (CH2)2O(CH2)2, etc.; R3 = Me, i-Pr, t-Bu, Ph, etc.] to form products containing a quaternary carbon atom at the nucleophile moiety and a tertiary carbon atom at the electrophile moiety is reported. Under relatively neutral conditions, the allylated aliphatic esters H2C:CHCH(R1)CR22CO2R3 were obtained with excellent regio- and enantioselectivity. These products were readily converted into primary alcs., carboxylic acids, amides, isocyanates, and carbamates, as well as THF and γ-butyrolactone derivatives, without erosion of enantiomeric purity.

Compounds in my other articles are similar to this one((11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine)Recommanded Product: (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II)(SMILESS: CC(C)(C1=O[Ni+2]2(O=C(C(C)(C)C)[CH-]1)O=C([CH-]C(C(C)(C)C)=O2)C(C)(C)C)C,cas:14481-08-4) is researched.Name: Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II). The article 《Atomic/molecular layer deposition of Ni-terephthalate thin films》 in relation to this compound, is published in Dalton Transactions. Let’s take a look at the latest research on this compound (cas:14481-08-4).

Atomic/mol. layer deposition (ALD/MLD) is currently strongly emerging as an intriguing route for novel metal-organic thin-film materials. This approach already covers a variety of metal and organic components, and potential applications related to e.g. sustainable energy technologies. Among the 3d metal components, nickel has remained unexplored so far. Here the authors report a robust and efficient ALD/MLD process for the growth of high-quality nickel terephthalate thin films. The films are deposited from Ni(thd)2 (thd: 2,2,6,6-tetramethyl-3,5-heptanedionate) and terephthalic acid (1,4-benzenedicarboxylic acid) precursors in the temperature range of 180-280°C, with appreciably high growth rates up to 2.3 Å per cycle at 200°C. The films are amorphous but the local structure and chem. state of the films are addressed based on XRR, FTIR and RIXS techniques.

Compounds in my other articles are similar to this one(Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II))HPLC of Formula: 14481-08-4, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The crystal structure of copper(II) succinate dihydrate》. Authors are O’Connor, B. H.; Maslen, E. N..The article about the compound:Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II)cas:14481-08-4,SMILESS:CC(C)(C1=O[Ni+2]2(O=C(C(C)(C)C)[CH-]1)O=C([CH-]C(C(C)(C)C)=O2)C(C)(C)C)C).Name: Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II). Through the article, more information about this compound (cas:14481-08-4) is conveyed.

The crystal structure of the title compound has been established by vector methods with 3-dimensional single crystal x-ray data. The at. parameters were refined by the diagonal least sqs. approximation, the final R index being 0.095. The crystal structure has P1̅ space-group symmetry and the coordinates are defined most suitable relative to a cell of dimensions a 6.437 ± 0.011, b 7.623 ± 0.004, c 8.081 ± 0.005 A., α 103° 54′ ± 8′, β 73° 30′ ± 21′, γ 98° 37′ ± 13′. The structure consists of infinite chains of covalently bonded binuclear units each of which closely resembles the Cu(OAc)2.H2O configuration. The Cu-Cu distance of 2.610(1) A. confirms that there is magnetic exchange between the two copper atoms in each binuclear unit.

Compounds in my other articles are similar to this one(Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II))Name: Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II), you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Cost-Effectiveness of Pembrolizumab Versus Carboplatin and Paclitaxel in Patients With Unresectable or Metastatic Melanoma After First-Line Treatment in China., published in 2021-12-16, which mentions a compound: 41575-94-4, Name is cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II), Molecular C6H12N2O4Pt, Computed Properties of C6H12N2O4Pt.

OBJECTIVE: This study aimed to evaluate the cost-effectiveness of pembrolizumab compared with standard-of-care chemotherapy (paclitaxel + carboplatin [PC]) in patients with unresectable or metastatic melanoma after first-line treatment from a Chinese healthcare system perspective. METHODS: We conducted a partitioned-survival model with a 1-week cycle length and a 20-year base-case time horizon. Piecewise parametric models were fitted to KEYNOTE-006 trial data to estimate progression-free survival and overall survival for pembrolizumab, and a network meta-analysis was used to estimate the clinical outcomes for standard of care. Quality-adjusted life-years (QALYs) were calculated using EQ-5D data from KEYNOTE-006, applying Chinese-specific utility tariffs. Costs included drug acquisition, administration, adverse events, and disease management, reflecting the Chinese pricing system. Chinese-specific disease management costs were estimated based on clinical opinion on health state resource use and chemotherapy-related adverse events. Costs and outcomes were discounted at 5% annually. Multiple deterministic and probabilistic sensitivity analyses were performed to test the robustness of the results. RESULTS: In the base-case analysis, the treatment of pembrolizumab is estimated to yield 2.63 life-years (LYs) and 2.24 QALYs at an incremental cost of ¥372 316.46 versus PC. The incremental costs per LY and per QALY were ¥141 771.00 and ¥165 865.69, respectively, the latter being below a threshold of 3 times the per capita gross domestic product (￥193 932) in China, deemed as cost-effective according to the World Health Organization threshold. These findings were robust against a wide range of sensitivity analyses. CONCLUSIONS: Pembrolizumab is projected as cost-effective compared with PC in patients with unresectable or metastatic melanoma after first-line treatment in China.

Compounds in my other articles are similar to this one(cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II))Computed Properties of C6H12N2O4Pt, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application In Synthesis of (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine, is researched, Molecular C36H30NO2P, CAS is 415918-91-1, about Highly Regio-, Diastereo- and Enantioselective Synthesis of Tetrahydroazepines and Benzo[b]oxepines through Palladium-Catalyzed [4+3] Cycloaddition Reactions. Author is Trost, Barry M.; Zuo, Zhijun.

A novel Pd0-catalyzed asym. [4+3] annulation reaction of two readily accessible starting materials was developed for building seven-membered heterocyclic architectures. The potential [3+2] side pathway could be suppressed though fine tuning of the conditions. A broad scope of cycloaddition donors and acceptors participated in the transformation with excellent chemo-, regio-, diastereo- and enantioselectivtities, leading to valuable tetrahydroazepines, e.g., I and benzo[b]oxepines, e.g., II.

Compounds in my other articles are similar to this one((11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine)Application In Synthesis of (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Chelate Effect in the Gas Phase. The Complexes of Ni(2,2,6,6-tetramethyl-3,5-heptanedionate)2 with Bidentate Ligands》. Authors are Emmenegger, Franzpeter; Schlaepfer, Carl Wilhelm; Stoeckli-Evans, Helen; Piccand, Michel; Piekarski, Henryk.The article about the compound:Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II)cas:14481-08-4,SMILESS:CC(C)(C1=O[Ni+2]2(O=C(C(C)(C)C)[CH-]1)O=C([CH-]C(C(C)(C)C)=O2)C(C)(C)C)C).Safety of Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II). Through the article, more information about this compound (cas:14481-08-4) is conveyed.

When a bidentate ligand L-L is added to the square planar Ni(tmhd)2 (tmhd = tetramethylheptanedionate), octahedral Ni(tmhd)2L-L (L-L = tetramethylethylenediamine (TEME), 2,2-bipyridine, dimethylaminomethoxyethane (MAO)) are formed. This reaction was studied by visible spectroscopy in toluene at 25° and in the gas phase between 150 and 350°. It allows the comparison on one hand of the chelate effect of three ligands forming five-membered chelate rings: (i) the flexible N-N ligand TEME; (ii) the rigid N-N ligand bpy; (iii) the flexible N-O ligand MAO. However, it allows the comparison of these ligands with the six-membered chelate ring-forming N-N ligand 1,3-tetramethylpropylenediamine (TEMP). From the temperature dependence of the gas-phase stability constants, enthalpies and entropies of the complex-forming reactions were derived. As there are no solvation effects in the gas phase, the reaction enthalpies are the metal-ligand bond enthalpies. This is of particular interest for the hemilabile ligand MAO. For the N-N ligands, the stability of the metal-ligand bonds decreases in the order TEME > bpy > TEMP. The entropy of the complex formation with the two flexible ligands TEME and MAO is the same, while it is slightly more pos. for the rigid bpy and a lot more pos. for TEMP. ΔformG°298 of the complexes is more neg. in the gas phase than in solution because the solvation energy of the reactants is more neg. than the solvation energy of the products. This is shown in detail for the formation of Ni(tmhd)2bpy where data of a complete thermodn. cycle are presented.

Compounds in my other articles are similar to this one(Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II))Safety of Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II), you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called CVD of thin oxygen permeable membrane films, published in 2003, which mentions a compound: 14481-08-4, mainly applied to oxide membrane CVD oxygen permeation, COA of Formula: C22H38NiO4.

Membranes with high mixed oxygen-ionic and electronic conductivity are of great interest for oxygen separation and catalytic membrane reactors for partial oxidation of hydrocarbons. In the diffusion regime oxygen flow through membrane is proportional to its reciprocal thickness and gas tight thin films are most promising for applications. In a single source (aerosol- and flash evaporation) CVD equipment using the mixtures of THD compounds as precursors a number of mixed-conductor layers, (La,Sr)(Ga,Fe)O3, (La,Sr)(Co,Fe)O3, La2NiO4 were deposited with a thickness 3-30 μm and typical deposition rate 10 μm/h. As substrates, various porous flat and tubular materials with a pore size up to 10 μm were tested. The film composition, microstructure and gas tightness were studied. Using post-annealing with oxide fluxes the membranes of the gas tightness high enough for applications were obtained.

Compounds in my other articles are similar to this one(Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II))COA of Formula: C22H38NiO4, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

COA of Formula: C36H30NO2P. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine, is researched, Molecular C36H30NO2P, CAS is 415918-91-1, about Enantioselective iridium-catalyzed allylic aminations of allylic carbonates with functionalized side chains. Asymmetric total synthesis of (S)-vigabatrin. Author is Gnamm, Christian; Franck, Geraldine; Miller, Nicole; Stork, Timon; Broedner, Kerstin; Helmchen, Guenter.

Iridium-catalyzed aminations of allylic carbonates containing a variety of O-functional groups have been explored. High degrees of regio- as well as enantioselectivity were achieved with diacylamides under salt-free conditions and with arylamines. The results allowed the antiepilepsy drug (S)-vigabatrin to be prepared via a very short route.

Compounds in my other articles are similar to this one((11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine)COA of Formula: C36H30NO2P, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics