Month: April 2022

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Gold-Catalyzed Reaction of Propargyl Esters and Alkynylsilanes: Synthesis of Vinylallene Derivatives through a Twofold 1,2-Rearrangement, published in 2021-11-22, which mentions a compound: 415918-91-1, Name is (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine, Molecular C36H30NO2P, Application of 415918-91-1.

The reaction of propargyl esters with alkynylsilanes under gold catalysis provides vinylallene derivatives through consecutive [1,2]-acyloxy/[1,2]-silyl rearrangements. Good yields, full atom-economy, broad substrate scope, easy scale-up and low catalyst loadings are salient features of this novel transformation. D. Functional Theory (DFT) calculations suggest a reaction mechanism involving initial [1,2]-acyloxy rearrangement to generate a gold vinylcarbene intermediate which upon regioselective attack of the alkynylsilane affords a vinyl cation which undergoes a type II-dyotropic rearrangement involving the silyl group and the metal fragment. Preliminary results on the enantioselective version of this transformation are also disclosed.

《Gold-Catalyzed Reaction of Propargyl Esters and Alkynylsilanes: Synthesis of Vinylallene Derivatives through a Twofold 1,2-Rearrangement》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine)Application of 415918-91-1.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 41575-94-4, is researched, Molecular C6H12N2O4Pt, about Anti-PD-(L)1 for KRAS-mutant advanced non-small-cell lung cancers: a meta-analysis of randomized-controlled trials, the main research direction is antiPDL KRAS mutant advanced NSCLC metaanalysis randomized controlled trial; Immunotherapy; KRAS; Meta-analysis; Non-small-cell lung cancer.Recommanded Product: 41575-94-4.

The most frequent mutation in advanced non-small-cell lung cancer (NSCLC), Kirsten rat-sarcoma viral oncogene (KRAS) is found in 20-25% of these patients’ tumors. While phase III trials on therapies targeting KRAS, especially KRASG12C, are ongoing, the clin. efficacy of anti-programmed death protein-1 (PD-1) or its ligand (PD-L1) against KRAS-mutant NSCLCs remains a topic of debate. This meta-anal. examined randomized-trial data comparing first- or second-line anti-PD-(L)1 with or without chemotherapy vs. chemotherapy alone for advanced KRAS-mutant NSCLCs. Outcome measures included overall survival (OS) and progression-free survival (PFS). Analyses were computed using the Cochrane method of collaboration for meta-analyses, with Review Manager software (RevMan version 5.3; Oxford, UK). We analyzed 3 first-line trials (IMpower-150, Keynote-189 and Keynote-042) and 3 second-line trials (Oak, Poplar and CheckMate-057) that included 1313 NSCLCs (386 KRAS-mutant and 927 KRAS wild-type tumors). For KRAS-mutant NSCLCs, anti-PD-(L)1 with or without chemotherapy was significantly associated (hazard ratio [95% confidence interval]) with prolonged OS (0.59 [0.49-0.72]; p < 0.00001) and PFS (0.58 [0.43-0.78]; p = 0.0003) compared to chemotherapy alone. OS benefited in both first- and second-line trials. OS for patients with KRAS-mutant NSCLCs was significantly longer than that for those with KRAS wild-type tumors (p = 0.001). Anti-PD-(L)1 with or without chemotherapy seemed to achieve longer OS and PFS than chemotherapy alone for patients with KRAS-mutant and wild-type KRAS advanced NSCLCs, with an even greater OS benefit for the former. 《Anti-PD-(L)1 for KRAS-mutant advanced non-small-cell lung cancers: a meta-analysis of randomized-controlled trials》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II))Recommanded Product: 41575-94-4.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Molecular Catalysis called Immobilized chiral rhodium nanoparticles stabilized by chiral P-ligands as efficient catalysts for the enantioselective hydrogenation of 1-phenyl-1,2-propanedione, Author is Ruiz, Doris; Maki-Arvela, Paivi; Aho, Atte; Chimentao, Ricardo; Claver, Carmen; Godard, Cyril; Fierro, Jose L. G.; Murzin, Dmitry Yu., which mentions a compound: 32305-98-9, SMILESS is CC1(C)O[C@@H](CP(C2=CC=CC=C2)C3=CC=CC=C3)[C@H](CP(C4=CC=CC=C4)C5=CC=CC=C5)O1, Molecular C31H32O2P2, Computed Properties of C31H32O2P2.

This work reports the efficient synthesis of enantio-enriched alcs. by asym. hydrogenation of 1-phenyl-1,2-propanedione using chiral nanoparticles (NPs) supported on SiO2. The chiral catalysts were synthesized by reducing the [Rh(μ-OCH3)(C8H12)]2 precursor under H2 in the presence of P-chiral ligands as stabilizers and SiO2 as support. Synthesis of catalysts in mild conditions was performed from labile organometallic precursor and chiral ligands provided small and well defined chiral nanoparticles (≤ 3 nm). The catalysts were characterized by XPS, HR-TEM, EDS, XRD and N2 physisorption isotherm. The phys. chem. properties of the materials were correlated with the catalytic results obtained in the asym. hydrogenation of 1-phenyl-1,2-propanedione. In 1-phenyl-1,2-propanedione hydrogenation the best results using chiral catalysts allowed 98% conversion and enantiomeric excess of 67% to (R)-1-hydroxy-1-phenyl-propan-2-one and 59% for (R)-2-hydroxy-1-phenylpropan-1-one. Catalyst recycling studies revealed that chiral nanoparticles immobilized on SiO2 are stable. These catalysts do not need extra amount of chiral modifier or inducer added in situ and could be reused without loss of enantioselectivity.

《Immobilized chiral rhodium nanoparticles stabilized by chiral P-ligands as efficient catalysts for the enantioselective hydrogenation of 1-phenyl-1,2-propanedione》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((((4R,5R)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphine))Computed Properties of C31H32O2P2.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

HPLC of Formula: 14481-08-4. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II), is researched, Molecular C22H38NiO4, CAS is 14481-08-4, about Thermochemical properties of nickel(II) β-diketonates. Author is Gerasimov, P. A.; Gerasimova, A. I.; Arkhipov, Yu. A.; Igumenov, I. K..

The heats of combustion and formation as well as sublimation heat at 298.15 K and sublimation pressures determined measured calorimetrically for Ni dipivaloylmethanate (Ni(DPM)2) and Ni diketoiminate (Ni(KI)2). Equations for the sublimation pressures as functions of absolute temperature are given for the intervals 364.7-385.4 and 348.1-358.3 K for Ni(DPM)2 and Ni(KI)2, resp.

《Thermochemical properties of nickel(II) β-diketonates》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II))HPLC of Formula: 14481-08-4.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Chemical vapour deposition of metastable Ni3N, published in 2009, which mentions a compound: 14481-08-4, Name is Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II), Molecular C22H38NiO4, SDS of cas: 14481-08-4.

Metastable nickel nitride (Ni3N) was chem. vapor deposited using bis(2,2,6,6-tetramethyl-3,5-heptanedionato)Ni(II) (Ni(thd)2) and ammonia precursors. The growth on both nonetched Si(100) and amorphous SiO2 is polycrystalline at deposition temperatures between 200-290°. However, at the highest temperatures the impurity level of oxygen and carbon originating from the metal precursor ligand, is ∼5%. The growth rate dependence of temperature is divided into three different regions with large differences in activation energies, interpreted as different factors controlling the growth. The deposition rate as a function of precursor supply as well as the incubation time for the growth initiation are different at temperatures which are further indications of differences in reaction mechanism. By substitution of NH3 for H2 to the reactant gas the growth mechanism occurs via surface -NHx groups.

《Chemical vapour deposition of metastable Ni3N》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II))SDS of cas: 14481-08-4.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Category: esters-buliding-blocks. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II), is researched, Molecular C6H12N2O4Pt, CAS is 41575-94-4, about Pre-operative Carboplatin/Paclitaxel Versus 5-Fluorouracil (5-FU)-based Chemoradiotherapy for Older Adults With Esophageal Cancer.. Author is Al-Jumayli, Mohammed; Choucair, Khalil; Al-Obaidi, Ammar; Park, Robin; Bansal, Ajay; Baranda, Joaquina; Sun, Weijing; Saeed, Anwaar.

BACKGROUND/AIM: This study aimed to compare the efficacy and tolerability of pre-operative platinum/5-fluorouracil (P5F) and carboplatin/paclitaxel (CP), in combination with radiation therapy in older adults with locally advanced, stage I-III esophageal cancer. PATIENTS AND METHODS: We retrospectively reviewed 51 patients aged ≥70 years who underwent chemoradiotherapy followed by esophagectomy for stage I-III esophageal cancer between 2008 and 2018. Pathological complete response (pCR) and survival rates were compared across the two chemotherapy regimen arms. RESULTS: Treatment completion (p=0.28), pCR (p=0.89), and partial response rates were similar across both chemotherapy groups. Overall survival (OS) and disease-free survival (DFS) were similar across both groups with HR=0.80 (p=0.62) and HR=0.72 (p=0.72) respectively. CONCLUSION: The lesser toxic CP regimen may be used in older patients with locally advanced esophageal cancer, with tumor response and survival rates similar to P5F chemotherapy.

《Pre-operative Carboplatin/Paclitaxel Versus 5-Fluorouracil (5-FU)-based Chemoradiotherapy for Older Adults With Esophageal Cancer.》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II))Category: esters-buliding-blocks.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 6-Bromo-8-methylquinoline. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 6-Bromo-8-methylquinoline, is researched, Molecular C10H8BrN, CAS is 178396-31-1, about Palladium-Catalyzed C-H Bond Functionalization Reactions Using Phosphate/Sulfonate Hypervalent Iodine Reagents. Author is He, Yimiao; Huang, Lilan; Xie, Limei; Liu, Peng; Wei, Qiongmei; Mao, Fangfang; Zhang, Xuehong; Huang, Jun; Chen, Sijing; Huang, Chusheng.

In the presence of Pd(OAc)2, 8-methylquinolines and 8-ethylquinoline underwent directed and regioselective oxidative phosphorylation, phosphination, sulfonylation, and hydroxylation reactions with (hydroxy)aryliodine phosphates, phosphinates, and sulfonates to yield 8-quinolinylmethyl phosphates, phosphinates, sulfonates, and alcs. 2-Arylpyridines underwent hydroxylation and arylation reactions under similar conditions to yield 2-(2-pyridinyl)phenols and biarylpyridines, resp. The quinolinylmethyl sulfonates underwent further substitution reactions.

《Palladium-Catalyzed C-H Bond Functionalization Reactions Using Phosphate/Sulfonate Hypervalent Iodine Reagents》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Bromo-8-methylquinoline)Reference of 6-Bromo-8-methylquinoline.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II). Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II), is researched, Molecular C22H38NiO4, CAS is 14481-08-4, about Surface Modification of CoOx Loaded BiVO4 Photoanodes with Ultrathin p-Type NiO Layers for Improved Solar Water Oxidation. Author is Zhong, Miao; Hisatomi, Takashi; Kuang, Yongbo; Zhao, Jiao; Liu, Min; Iwase, Akihide; Jia, Qingxin; Nishiyama, Hiroshi; Minegishi, Tsutomu; Nakabayashi, Mamiko; Shibata, Naoya; Niishiro, Ryo; Katayama, Chisato; Shibano, Hidetaka; Katayama, Masao; Kudo, Akihiko; Yamada, Taro; Domen, Kazunari.

Photoelectrochem. (PEC) devices that use semiconductors to absorb solar light for water splitting offer a promising way toward the future scalable production of renewable hydrogen fuels. However, the charge recombination in the photoanode/electrolyte (solid/liquid) junction is a major energy loss and hampers the PEC performance from being efficient. Here, we show that this problem is addressed by the conformal deposition of an ultrathin p-type NiO layer on the photoanode to create a buried p/n junction as well as to reduce the charge recombination at the surface trapping states for the enlarged surface band bending. Further, the in situ formed hydroxyl-rich and hydroxyl-ion-permeable NiOOH enables the dual catalysts of CoOx and NiOOH for the improved water oxidation activity. Compared to the CoOx loaded BiVO4 (CoOx/BiVO4) photoanode, the ∼6 nm NiO deposited NiO/CoOx/BiVO4 photoanode triples the photocurrent d. at 0.6 VRHE under AM 1.5G illumination and enables a 1.5% half-cell solar-to-hydrogen efficiency. Stoichiometric oxygen and hydrogen are generated with Faraday efficiency of unity over 12 h. This strategy could be applied to other narrow band gap semiconducting photoanodes toward the low-cost solar fuel generation devices.

《Surface Modification of CoOx Loaded BiVO4 Photoanodes with Ultrathin p-Type NiO Layers for Improved Solar Water Oxidation》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II))Reference of Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II).

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Safety of Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II). The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II), is researched, Molecular C22H38NiO4, CAS is 14481-08-4, about Synthesis of undoped and Ni doped InTaO4 photoactive thin films by metal organic chemical vapor deposition. Author is McSporran, N.; Rico, V.; Borras, A.; Gonzalez-Elipe, A. R.; Sauthier, G.; Gyoergy, E.; Santiso, J.; Garcia, G.; Figueras, A.; Parafianovic, L.; Abrutis, A..

Indium tantalate (InTaO4) and nickel doped InTaO4, In1-xNixTaO4 (x = 0.1), thin films were grown by Pulsed Injection Metal Organic Chem. Vapor Deposition (PI-MOCVD). The deposition was carried out using as precursors a solution of Ta(OC2H5)5 and In(THD)3 in toluene for the InTaO4 and Ta(OC2H5)5, In(THD)3 and Ni(THD)2 in toluene for the In1-xNixTaO4 thin films. The compounds formation, films stoichiometry and crystalline structure were studied as a function of substrate temperature and precursors concentration Crystalline and stoichiometric (indium/tantalum at. ratio of 1) films were obtained under optimized deposition conditions. Post-deposition heat treatment in N2 or O2 atmospheres further improved the crystalline quality of the films. Under optimum growth conditions the films showed no phase segregations, a feature that makes them suitable for future photocatalytic applications. The study of hydrophilic activities of In1-xNixTaO4 thin films evidenced a decrease of the water contact angle up to 60° under visible light irradiation and a complete transformation in a superhydrophilic state upon UV irradiation

《Synthesis of undoped and Ni doped InTaO4 photoactive thin films by metal organic chemical vapor deposition》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II))Safety of Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II).

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Oncogene called Novel function of THEMIS2 in the enhancement of cancer stemness and chemoresistance by releasing PTP1B from MET, Author is Huang, Wei-Chieh; Yen, Jia-Hau; Sung, Yu-Wen; Tung, Shiao-Lin; Chen, Po-Ming; Chu, Pei-Yi; Shih, Ya-Chi; Chi, Hsiang-Cheng; Huang, Yi-Ching; Huang, Shih-Jei; Wang, Lu-Hai, which mentions a compound: 41575-94-4, SMILESS is O=C1C2(CCC2)C(O[Pt]O1)=O.N.N, Molecular C6H12N2O4Pt, Category: esters-buliding-blocks.

Triple neg. breast cancer (TNBC) possesses poor prognosis mainly due to lack of effective endocrine or targeted therapies, aggressive nature and high rate of chemoresistance. Cancer stem cells (CSCs) are considered to play critical roles in cancer recurrence and chemoresistance. THEMIS2 was identified as the sole common elevated gene in three triple neg. breast cancer (TNBC) and two ovarian CSC lines. We discovered an intrinsic signaling scaffold function of THEMIS2, which acts as a novel regulator of cancer stemness in promoting multiple cancer stemness properties including sphere formation, stemness markers expression, chemoresistance and tumorigenicity with low numbers of cancer cells implantation. For the first time, we demonstrated that THEMIS2 specifically enhanced MET activating phosphorylation by suppressing the association of protein-tyrosine phosphatases 1B (PTP1B) with p-MET and MET, which accounted mainly for THEMIS2-mediated effect on cancer stemness and chemoresistance. Increased THEMIS2 expression was associated with poor survival in TNBC patients and in patients from our breast cancer cohort. We found that non-cytotoxic dosages of cryptotanshinone (CPT) could potently inhibit cancer stemness, chemoresistance and tumorigenicity by suppressing expression of THEMIS2. Notably, stable overexpression of THEMIS2 is associated with enhanced sensitivity toward Capmatinib and CPT treatment. Expression levels of THEMIS2 and p-MET protein were pos. correlated in the 465 breast cancer specimens. Our study revealed the novel oncogenic role of THEMIS2 and its underlying mechanism via suppressing PTP1B association with MET and thus leading to its activation. Our findings suggest that THEMIS2 could be a biomarker for MET targeted therapy and also provide a potential clin. application using low dosages of CPT for treatment of THEMIS2 pos. TNBC.

《Novel function of THEMIS2 in the enhancement of cancer stemness and chemoresistance by releasing PTP1B from MET》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II))Category: esters-buliding-blocks.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics