Month: April 2022

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Carboplatin-paclitaxel in triple-negative metastatic breast cancer during pregnancy with neoplastic thrombosis.》. Authors are Monari, Francesca; Grandi, Giovanni; Guidotti, Isotta; Torcetta, Francesco; Battista, Rachele; Coluccio, Valeria; Piombino, Claudia; Moscetti, Luca; Neri, Isabella; Toss, Angela.The article about the compound:cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)cas:41575-94-4,SMILESS:O=C1C2(CCC2)C(O[Pt]O1)=O.N.N).Recommanded Product: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II). Through the article, more information about this compound (cas:41575-94-4) is conveyed.

The treatment of breast cancer (BC) diagnosed during pregnancy is a challenging situation for the patient, family and healthcare providers. Here we describe the case of a 35-year-old woman diagnosed with a triple-negative breast cancer relapse during pregnancy. She previously underwent neoadjuvant chemotherapy without any response, subsequent left skin sparing mastectomy plus axillary node dissection and radiation therapy to the chest wall and supraclavicular lymph nodes. Two years later, during her first single pregnancy, the patient presented a subclavian vein thrombosis and a BC relapse to locoregional lymph nodes. At 24 weeks of gestation, a first line treatment with weekly paclitaxel and carboplatin was started. Considering the disease progression after two complete cycles of chemotherapy, the patient had an elective caesarean section at 32+6 weeks. A full-body CT-scan and a PET-scan after the delivery showed a massive neoplastic thrombosis involving the left jugular, brachiocephalic and internal mammary vein, as well the superior vena cava and the right atrium. Few data are available on platinum-based chemotherapy during pregnancy in BC patients. Nevertheless, the choice of therapy was conditioned by the previous absence of response to anthracycline and taxane. In case of BC diagnosis during pregnancy, a multidisciplinary management as in the case described is recommended to increase the chance of survival both for the patients and their babies.

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Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Total synthesis of (+)-spiroindimicin A via asymmetric palladium-catalyzed spirocyclization, published in 2021, which mentions a compound: 415918-91-1, Name is (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine, Molecular C36H30NO2P, Name: (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine.

The spiroindimicins are a unique class of chlorinated indole alkaloids characterized by three heteroaromatic rings structured around a congested spirocyclic stereocenter. Here, we report the first total synthesis of (+)-spiroindimicin A (I), which bears a challenging C-3’/C-5”-linked spiroindolenine. We detail our initial efforts to effect a biomimetic oxidative spirocyclization from its proposed natural precursor, lynamicin D, and describe how these studies shaped our final abiotic 9-step solution to this complex alkaloid built around a key asym. Pd-catalyzed spirocyclization. Scalable access to spiroindimicins A, H, and their congeners has enabled discovery of their activity against several parasites relevant to human health, providing potential starting points for new therapeutics for the neglected tropical diseases leishmaniasis and African sleeping sickness.

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Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Effects of Catalyst Activation and Ligand Steric Properties on the Enantioselective Allylation of Amines and Phenoxides, published in 2005-03-17, which mentions a compound: 415918-91-1, Name is (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine, Molecular C36H30NO2P, Recommanded Product: (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine.

The yields, enantioselectivities, and regioselectivities of the reactions of amines and phenoxides with allylic carbonates in the presence of a metallacyclic iridium catalyst were compared. These data show that both preactivation of the catalyst and the size of the ligand affect the yield, enantioselectivity, and regioselectivity. With the activated catalyst containing a bis-naphthethylamino group, the allylic amination and etherification of a broad range of allylic carbonates occurred in high yields and with high regioselectivities and enantioselectivities.

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Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Safety of (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine, is researched, Molecular C36H30NO2P, CAS is 415918-91-1, about Formation of quaternary centres by copper catalysed asymmetric conjugate addition to β-substituted cyclopentenones with the aid of a quantitative structure-selectivity relationship. Author is Ardkhean, Ruchuta; Mortimore, Mike; Paton, Robert S.; Fletcher, Stephen P..

A new asym. conjugate addition method was developed for β-substituted cyclopentenones to form quaternary centers using alkylzirconocene nucleophiles giving up to 97% yield and 92% ee. Key to the reaction’s success was the design of suitable phosphoramidite ligands which was aided by a linear quant. structure-selectivity relationship (QSSR). QSSR models were created from the ligand screening data (a total of 36 ligands) which revealed important electronic and steric requirements and led to the synthesis of more enantioselective ligands. DFT calculations of competing transition structures enable the interpretation of the electronic and steric terms present in the QSSR models.

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Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (((4R,5R)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphine), is researched, Molecular C31H32O2P2, CAS is 32305-98-9, about Nickel(0)-Catalyzed Asymmetric Ring Expansion Toward Enantioenriched Silicon-Stereogenic Benzosiloles, the main research direction is benzosilole silicon stereogenic chiral preparation fluorescence CD spectra absorbance; crystal structure mol benzosilole silicon stereogenic chiral preparation; nickel catalyst stereoselective ring expansion chiral silacyclobutane; C-Si bond cleavage; asymmetric catalysis; chiral benzosiloles; silacyclobutanes; silicon-stereogenic center.Name: (((4R,5R)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphine).

The development of a straightforward strategy to obtain enantioenriched silicon-stereogenic benzosiloles remains a challenging yet appealing synthesis venture due to their potential future application in chiral electronic and optoelectronic devices. In this context, all of the existing methods rely on Rh-catalyzed systems and are somewhat limited in scope. Herein, we disclose the first Ni0-catalyzed ring expansion process that enables the preparation of benzosiloles possessing tetraorganosilicon stereocenters in excellent yields and enantioselectivities. The presented catalysis strategy is further applied to the asym. synthesis of silicon-stereogenic bis-silicon-bridged π-extended systems. Preliminary studies reveal that such compounds exhibit fluorescence emission, Cotton effects and circularly polarized luminescence (CPL) activity.

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Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Name: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II). The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II), is researched, Molecular C6H12N2O4Pt, CAS is 41575-94-4, about Assessment of quality of life among advanced ovarian cancer patients in a tertiary care hospital in India.. Author is Sarkar, Sinjini; Sahoo, Pranab K; Pal, Ranita; Mistry, Tanuma; Mahata, Sutapa; Chatterjee, Puja; Vernekar, Manisha; Mandal, Syamsundar; Bera, Tanmoy; Nasare, Vilas D.

PURPOSE: The study aims to record the quality of life (Qol) and its changes while ovarian cancer (OC) patients undergo debulking surgeries and chemotherapy in a tertiary care hospital of Eastern India. METHODS: Patients with advanced epithelial OC (FIGO stages III-IV) were recruited. They underwent primary/interval debulking surgeries with classical chemotherapy (adjuvant/neoadjuvant) of intravenous tri-weekly doses of paclitaxel + carboplatin. QoL was assessed using Fact- O + FACIT-Sp-12 questionnaire with a set of 51 questions in different domains (spiritual, physical, social, emotional, and functional factors) and a special set for OC patients under the heading “”Additional concerns.”” The responses from patients were recorded at baseline (diagnosis/study entry), 2, 4, and 6 months during the treatment visits. Overall survival (OS) was assessed using Kaplan Meier curve. RESULTS: A majority of patients were 49.15±10.8 years of age, school-educated (54%), unemployed/homemakers (73.5%), belonging from rural setup (64.6%) with a monthly income of Rs. 2000/- to Rs. 5000/-. There was no statistically significant (p>0.05) improvement found in Qol from the baseline till the end of the study, neither overall nor in subsets (responders (Rs)/partial responders (PRs)/non-responder (NRs) groups or the adjuvant and neoadjuvant chemotherapy groups). The common toxicities like anemia, constipation, and weight loss were significantly (p<0.05) correlated with the patients' physical, functional, emotional, and social well-being. CONCLUSION: Ovarian cancer patients represent a poor functional, social, and disease-specific quality of life that needs to be addressed, identified, and improved by the growing nexus of healthcare providers and researchers. I hope my short article helps more people learn about this compound(cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II))Name: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II). Apart from the compound(41575-94-4), you can read my other articles to know other related compounds.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Steib, Philip; Breit, Bernhard published the article 《Concise Total Synthesis of (-)-Vermiculine through a Rhodium-Catalyzed C2-Symmetric Dimerization Strategy》. Keywords: vermiculine total synthesis rhodium catalyzed enantioselective dimerization; Wacker-type oxidation; antibiotics; dimerization; metathesis; total synthesis; vermiculine.They researched the compound: (((4R,5R)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphine)( cas:32305-98-9 ).Application In Synthesis of (((4R,5R)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphine). Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:32305-98-9) here.

A short and efficient synthesis of the C2-sym. antibiotic (-)-vermiculine (I) by utilizing an enantioselective catalytic one-step dimerization methodol. as key-step to construct the core structure is reported. The late-stage modifications feature a double metathesis homologation followed by a double Wacker-type oxidation These key-steps allowed the synthesis of vermiculine in only seven steps, starting from com. available building blocks.

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Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Product Details of 14481-08-4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II), is researched, Molecular C22H38NiO4, CAS is 14481-08-4, about Molecular characterization of nickel and vanadium nonporphyrin compounds found in heavy crude petroleums and bitumens.

Electron impact mass spectroscopy (EIMS) anal. of the fractions of pyridine/water extracts of selected crude petroleums, separated by HPLC indicated V porphyrins in Cerro Negro and Wilmington moderate polar fractions and possibly in the Wilmington low polar fraction. The EIMS results provided no addnl. information on the metallo-nonporphyrins. Further purification of the highly polar fraction of the Wilmington crude petroleum extract showed the bonding for ≥1 type of Ni-containing nonporphyrin compound This Ni is bound as carboxylates. HPLC anal. of gilsonite (bitumen) indicated that the Ni is predominantly bound as metallopetroporphyrin, while a small portion eluted as a highly polar metallo-nonporphyrin fraction.

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Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Real-world Overall Survival Using Oncology Electronic Health Record Data: Friends of Cancer Research Pilot》. Authors are Lasiter, Laura; Tymejczyk, Olga; Garrett-Mayer, Elizabeth; Baxi, Shrujal; Belli, Andrew J.; Boyd, Marley; Christian, Jennifer B.; Cohen, Aaron B.; Espirito, Janet L.; Hansen, Eric; Sweetnam, Connor; Robert, Nicholas J.; Small, Mackenzie; Stewart, Mark D.; Izano, Monika A.; Wagner, Joseph; Natanzon, Yanina; Rivera, Donna R.; Allen, Jeff.The article about the compound:cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)cas:41575-94-4,SMILESS:O=C1C2(CCC2)C(O[Pt]O1)=O.N.N).Reference of cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II). Through the article, more information about this compound (cas:41575-94-4) is conveyed.

In prior work, Friends of Cancer Research convened multiple data partners to establish standardized definitions for oncol. real-world end points derived from electronic health records (EHRs) and claims data. Here, we assessed the performance of real-world overall survival (rwOS) from data sets sourced from EHRs by evaluating the ability of the end point to reflect expected differences from a previous randomized controlled trial across five data sources, after applying inclusion/exclusion criteria. The KEYNOTE-189 clin. trial protocol of platinum doublet chemotherapy (chemotherapy) vs. programmed cell death protein 1 (PD-1) in combination with platinum doublet chemotherapy (PD-1 combination) in first-line nonsquamous metastatic non-small cell lung cancer guided retrospective cohort selection. The Kaplan-Meier product limit estimator was used to calculate 12-mo rwOS with 95% confidence intervals (CIs) in each data source. Cox proportional hazards models estimated hazard ratios (HRs) and associated 95% CIs, controlled for prognostic factors. Once the inclusion/exclusion criteria were applied, the five resulting data sets included 155 to 1,501 patients in the chemotherapy cohort and 36 to 405 patients in the PD-1 combination cohort. Twelve-month rwOS ranged from 45% to 58% in the chemotherapy cohort and 44% to 68% in the PD-1 combination cohort. The adjusted HR for death ranged from 0.80 (95% CI: 0.69, 0.93) to 1.15 (95% CI: 0.71, 1.85), controlling for age, gender, performance status, and smoking status. This study yielded insights regarding data capture, including ability of real-world data to precisely identify patient populations and the impact of criteria on end points. Sensitivity analyses could elucidate data set-specific factors that drive results.

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Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 178396-31-1. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Bromo-8-methylquinoline, is researched, Molecular C10H8BrN, CAS is 178396-31-1, about Iodonium Ylides as Carbene Precursors in Rh(III)-Catalyzed C-H Activation. Author is Jiang, Yuqin; Li, Pengfei; Zhao, Jie; Liu, Bingxian; Li, Xingwei.

The rhodium(III)-catalyzed coupling of C-H substrates with iodonium ylides has been realized for the efficient synthesis of diverse cyclic skeletons, where the iodonium ylides have been identified as efficient and outstanding carbene precursors. The reaction systems are applicable to both sp2 and sp3 C-H substrates under mild and redox-neutral conditions. The catalyst loading can be as low as 0.5 mol % in a gram-scale reaction. Representative products exhibit cytotoxicity toward human cancer cells at nanomolar levels.

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Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics