Month: April 2022

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)(SMILESS: O=C1C2(CCC2)C(O[Pt]O1)=O.N.N,cas:41575-94-4) is researched.Computed Properties of C22H38NiO4. The article 《Patient reported outcomes for cisplatin and radiation followed by carboplatin/paclitaxel versus carboplatin/paclitaxel for locally advanced endometrial carcinoma: An NRG oncology study.》 in relation to this compound, is published in Gynecologic oncology. Let’s take a look at the latest research on this compound (cas:41575-94-4).

INTRODUCTION: Chemotherapy plus radiation (Cis-RT + CP) did not demonstrate superiority in prolonging relapse-free survival compared to chemotherapy alone in patients with stage III or IVA endometrial carcinoma. The impact of treatment on quality of life (QOL), neurotoxicity (NTX) and psychometric properties of the gastrointestinal (GI) symptoms subscale during treatment and up to 1 year are described herein. METHODS: QOL assessments were scheduled at baseline, 6 weeks (post completion of RT (Cis-RT + CP) or prior to cycle 3 (CP)), then 18 weeks (end of treatment) and 70 weeks (1 year after the end of treatment) after starting treatment. QOL instruments included the FACT-En TOI, FACT/GOG-neurotoxicity (Ntx) subscale (short), and the gastrointestinal (GI) symptoms subscale. RESULTS: At the end of treatment, patients receiving Cis-RT + CP reported a statistically significant decreased QOL when compared to CP. The decline in QOL was reflected in physical well-being, functional well-being, and endometrial cancer specific concerns, but the minimally important differences (MID) were not considered clinically meaningful. Patients in both groups reported increased chemotherapy-induced Ntx symptoms with the CP group having worse scores and reaching peak symptoms at the time of chemotherapy completion. Patients on Cis-RT + CP reported statistically significantly worse GI symptoms after radiation therapy compared to patients on CP, this occurred across assessment intervals, though the MID was not meaningful. Psychometric evaluations indicated that the GI symptom scale is reliable, valid, and responsive to change. CONCLUSIONS: PROs indicate that the chemoradiotherapy group experienced worse HRQoL and GI toxicity compared to patients randomized to chemotherapy alone for locally advanced endometrial cancer though based on the MID, these were not clinically meaningful differences. The GI symptom subscale was a reliable and valid scale that has value for future trials. TRIAL REGISTRATION: NCT00942357.

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Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Foulds, Gary A.; Bennett, Alison M.; Thornton, David A.; Brown, Stephen J.; Clutterbuck, Linda M.; Hinton, Cassandra; Humphreys, Geoffrey B.; Masters, Anthony F. published the article 《Ligand donor atom and substituent effects in olefin oligomerization and isomerization catalyzed by nickel-based catalyst systems》. Keywords: olefin isomerization oligomerization catalyst; nickel based catalyst.They researched the compound: Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II)( cas:14481-08-4 ).Computed Properties of C22H38NiO4. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:14481-08-4) here.

The olefin oligomerization and isomerization catalytic activities and selectivities of catalysts generated by combining [Ni(RC(X)CHC(Y)R)2]n (R = Me, X = Y = O, n = 3; X = O, Y = NH, n = 1; X = O, Y = S, n = 1; X = Y = S, n = 1; and R = tert-Bu, n = 1, X = Y = O; X = O, Y = S; X = Y = S) and [Ni(CH3C(S)CHC(S)CH3)(PR3)Cl] (R = alkyl, aryl) precursors with [Et6-xAl2Clx] (x = 0, 2, 3, 4, 6) co-catalysis have been compared. All catalysts exhibit some olefin isomerization activity, but only those generated from precursors containing oxygen-donor ligands exhibit olefin oligomerization activity. Olefin oligomerization is also favored by the use of [EtAlCl2]2 as a co-catalyst. Almost no activity for either olefin oligomerization or isomerization was observed when using [Ni(CH3C(S)CHC(S)CH3)2] as a catalyst precursor. However, extremely active olefin oligomerization and isomerization catalysts could be generated from [Ni(CH3C(S)CHC(S)CH3)(PBu3)Cl] and appropriate co-catalysts. The mol.-weight of the products could be controlled in these systems by varying the co-catalyst. The catalysts with the most sustained high activity were those generated from [Ni(CH3C(S)CHC(S)CH3)(PBu3)Cl].

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Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Category: esters-buliding-blocks. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II), is researched, Molecular C22H38NiO4, CAS is 14481-08-4, about MOCVD of thin mixed-conducting films on porous ceramic substrates. Author is Stiens, Dirk; Wahl, Georg; Garcia, Gemma; Van Veen, Andre; Rebeilleau, Michael.

Dense layers of La nickelate were deposited by MOCVD on tubular porous ceramic substrates (100 mm length, 10 mm outer diameter, 110 nm pore size). Initial room temperature N leak rates of the layers of ≈18 μm thickness were as low as 7 × 10-8 mol s-1 cm-2 at Δp = 0.5 bar. Uniform film composition and thickness over the entire substrate length was verified by cross-sectional SEM and EDX anal. XRD anal. showed that the deposited material obtained at 480° is amorphous. Annealing at 800° lead to formation of a mixture of La2NiO4 and LaNiO3 phases.

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Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yu, Si-min; Snavely, William K.; Chaudhari, Raghunath V.; Subramaniam, Bala published an article about the compound: (((4R,5R)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphine)( cas:32305-98-9,SMILESS:CC1(C)O[C@@H](CP(C2=CC=CC=C2)C3=CC=CC=C3)[C@H](CP(C4=CC=CC=C4)C5=CC=CC=C5)O1 ).Quality Control of (((4R,5R)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(diphenylphosphine). Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:32305-98-9) through the article.

Rh-catalyzed hydroformylation of butadiene to adipaldehyde is a promising alternative route for producing valuable C6 compounds such as adipic acid and hexamethylenediamine. Fundamental insights into reaction pathways, aimed at enhancing adipaldehyde yield, were obtained from temporal concentration profiles and in situ ReactIR studies of butadiene hydroformylation on Rh complexes at 80°C and 14 bar syngas (molar CO/H2 = 1) pressure in a batch reactor. Specifically, the effects of operating conditions and eight com. available ligands on activity and selectivity were systematically investigated. It was found that the adipaldehyde selectivity is independent of the ligand/Rh ratio, rhodium concentration, butadiene concentration and syngas pressure, but significantly dependent on the type of ligand used. For example, while the DIOP ligand provided an adipaldehyde yield of ∼40% with butadiene as a substrate, the 6-DPPon ligand gave a maximum adipaldehyde yield of ∼93% with 4-pentenal as substrate. Furthermore, the adipaldehyde selectivity correlates well with the natural bite angle of the various ligands. ReactIR studies suggest that the preferential formation of the stable rhodium η3-crotyl complex with the various Rh complexes may be the main reason for the low adipaldehyde selectivity.

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Outcomes of prophylactic cranial irradiation in patients with small cell lung cancer in the modern era of baseline magnetic resonance imaging of the brain, published in 2022, which mentions a compound: 41575-94-4, mainly applied to prophylactic cranial irradiation human lung cancer brain magnetic imaging; Small-cell lung cancer; prophylactic cranial irradiation; brain magnetic resonance imaging; brain metastases; limited-stage small-cell lung cancer; extensive-stage small-cell lung cancer, Application In Synthesis of cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II).

For decades many patients with small cell lung cancer (SCLC) have been offered prophylactic cranial irradiation (PCI) to prevent brain metastases (BM). However, the role of PCI is debated in the modern era of increased brain magnetic resonance imaging (MRI) availability. BM in SCLC patients may respond to chemotherapy, and if a neg. MRI is used in the decision to use of PCI in the treatment strategy, the timing of brain MRI may be crucial when evaluating the effect of PCI. This retrospective study investigates the impact of PCI outcomes in patients with SCLC staged with brain MRI prior to chemotherapy. This study included 245 patients diagnosed SCLC/mixed NSCLC-SCLC treated between 2012 and 2019. The population was analyzed sep. for limited disease (LS-SCLC) and extensive disease (ES-SCLC). Patients were divided into groups based on baseline brain MRI prior to chemotherapy and PCI. The primary endpoint was time to symptomatic BM. Secondary endpoints were overall survival (OS), and progression-free survival (PFS). In patients with LS-SCLC staged with brain MRI the probability of developing symptomatic BM at one year was 4% vs. 22% (p < 0.05), median OS was 55 vs. 24 mo (p < 0.05), and median PFS was 30 vs. 10 mo (p < 0.05) with and without PCI, resp. No differences in probability of symptomatic BM and survival outcomes were observed in ES-SCLC. In a multivariate regression anal., no variables were statistically significant associated with the risk of developing symptomatic BM in patients with LS-SCLC and ES-SCLC. For patients with ES-SCLC staged with brain MRI, PS (HR = 3.33, CI; 1.41-7.89, p < 0.05) was associated with poor survival. This study found that PCI in LS-SCLC patients staged with brain MRI had lower incidence of symptomatic BM and improved survival outcomes suggesting PCI as standard of care. Similar benefit of PCI in patients with ES-SCLC was not found. There are many compounds similar to this compound(41575-94-4)Application In Synthesis of cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II). if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 6-Bromo-8-methylquinoline, is researched, Molecular C10H8BrN, CAS is 178396-31-1, about Rhodium(III)-catalyzed alkenylation reactions of 8-methylquinolines with alkynes by C(sp3)-H activation, the main research direction is methylquinoline alkyne alkenylation carbon hydrogen bond activation rhodium catalyst; allyl quinoline preparation mol crystal structure; CH activation; alkynes; regioselectivity; rhodium; synthetic methods.Safety of 6-Bromo-8-methylquinoline.

The alkenylation reactions of 8-methylquinolines with alkynes, catalyzed by [{Cp*RhCl2}2], proceeds efficiently to give 8-allylquinolines in good yields by C(sp3)-H bond activation. These reactions are highly regio- and stereoselective. A catalytically competent five-membered rhodacycle was structurally characterized, thus revealing a key intermediate in the catalytic cycle. The structures of the compounds were determined by spectroscopic data and confirmed by single crystal x-ray diffraction anal. of 8-(2,3-diphenylallyl)quinoline (I) and pentamethylcyclopentadienylchlororhodium complex of 8-methylquinoline (II). The crystallog. data were deposited at the Cambridge Crystallog. Data Center as supplementary publication number CCDC 978941 for I and CCDC 978942 for II.

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Ester – Wikipedia,
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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 323196-43-6, is researched, SMILESS is O=C1N(C)C(C)(C)N[C@@H]1CC2=CC=CC=C2.[H]Cl, Molecular C13H19ClN2OJournal, Polymer Chemistry called Immobilization of MacMillan catalyst via controlled radical polymerization: catalytic activity and reuse, Author is Moore, Beth L.; Lu, Annhelen; Longbottom, Deborah A.; O’Reilly, Rachel K., the main research direction is MacMillan catalyst Diels Alder reaction kinetics cyclopentadiene trans hexenal; tyrosine methacrylate catalyst RAFT polymerization DEGMA MacMillan.Product Details of 323196-43-6.

The MacMillan catalyst is an established organocatalyst capable of catalyzing a variety of organic reactions. Through the synthesis of a novel monomer containing the MacMillan catalytic functionality, a variety of copolymers were synthesized with the comonomer, diethylene glycol Me ether methacrylate (DEGMA). Reversible addition-fragmentation chain transfer (RAFT) polymerization was used for the synthesis of these functional polymers with good control over mol. weight, catalyst incorporation and polydispersity. These polymers showed lower critical solution temperature (LCST) behavior where the cloud point is dependent upon the degree of catalyst incorporation and catalyst loading also has an effect on the Tg of the copolymers. The catalytic activity of the functional copolymers is demonstrated by the Diels-Alder reaction between cyclopentadiene and trans-hexen-1-al and shows enantioselectivity close to those previously reported by MacMillan. The polymers can be reused in multiple Diels-Alder reactions via a pseudo continuous process, maintaining high conversion and enantioselectivity throughout the cycles.

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called A convenient catalytic asymmetric conjugate addition reaction to enones using alkylzirconium reagents, published in 2013-10-01, which mentions a compound: 415918-91-1, Name is (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine, Molecular C36H30NO2P, Recommanded Product: 415918-91-1.

Alkylzirconium reagents undergo highly enantioselective copper-catalyzed 1,4-addition reaction to cyclic enones. These reactions use alkylmetal species generated in situ from alkenes and the Schwartz reagent, and do not require premade organometallic reagents. The reactions have been performed on practical synthetic scales (2.5 mmol) and a scale-up to 10 mmol is demonstrated. The reactions proceed at room temperature, in a variety of solvents, and tolerate many functional groups.

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Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of C22H38NiO4. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)nickel(II), is researched, Molecular C22H38NiO4, CAS is 14481-08-4, about Catalyst enhanced chemical vapor deposition of nano-particle nickel films on Teflon surface. Author is Liu, Endong; Feng, Wenfang; Zhou, Jinlan; Yu, Kaichao.

Films formed with nanosized nickel particles on teflon surface were prepared by means of catalyst enhanced chem. vapor deposition (CECVD) with Ni(dmg)2, Ni(acac)2, Ni(hfac)2, Ni(TMHD)2, and Ni(cp)2 as precursors, and complexes Pd(hfac)2, PdCl2, and Pd(η3-2-methylallyl)acac as catalyst under carrier gas (H2). The film growth rate depends on the precursors and substrate temperature The chem. value, purity and surface morphol. of the Ni particle films were characterized by XPS and SEM. The films obtained were shiny with silvery color, and consisted of grains with a particle size of 50-140 nm. The Ni was metallic of which the purity was about 90-95% from XPS anal. SEM micrograph showed that the film had good morphol.

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine( cas:415918-91-1 ) is researched.Quality Control of (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine.Graening, Timm; Hartwig, John F. published the article 《Iridium-Catalyzed Regio- and Enantioselective Allylation of Ketone Enolates》 about this compound( cas:415918-91-1 ) in Journal of the American Chemical Society. Keywords: ketone chemoselective regioselective enantioselective preparation; chemoselective regioselective enantioselective substitution allylic carbonate silyl enol ether; stereoselective substitution allylic carbonate iridium phosphoramidite metallocyclic catalyst; cesium zinc fluoride catalyst stereoselective silyl enol ether allylation; formation iridium phosphoramidite metallocycle enantioselective substitution allylic carbonate enolate; regioselective enantioselective ketone enolate allylation allylic carbonate iridium phosphoramidite. Let’s learn more about this compound (cas:415918-91-1).

Regio- and enantioselective α-allylation of Me ketone silyl enol ethers RC(OSiMe3):CH2 (R = Ph, 2-MeOC6H4, Me2CH, PhCH2CH2) with unsym. allylic carbonates (E)-R1CH:CHCH2OC(:O)OCMe3 [R1 = 4-MeOC6H4, 4-F3CC6H4, 2-furyl, Me2CH, EtCH2, (E)-MeCH:CH] in the presence of iridium metallocycles derived from bis[(1,5-cyclooctadiene)iridium(I) chloride] and nonracemic phosphoramidites such as I (or its enantiomer), cesium fluoride, and zinc fluoride yields nonracemic branched ketones RCOCH2CHR1CH:CH2 [R = Ph, 2-MeOC6H4, Me2CH, PhCH2CH2; R1 = 4-MeOC6H4, 4-F3CC6H4, 2-furyl, Me2CH, EtCH2, (E)-MeCH:CH] in 46-94% yields, 85:15-99:1 regioselectivities, and in 91-96% ee. CsF and ZnF2 are both necessary for the allylation reactions; no reaction occurs in the absence of cesium fluoride while reaction with decreased regio- and chemoselectivity occurs in the absence of zinc fluoride. 31P NMR of iridium complexes of I and bis[(1,5-cyclooctadiene)iridium(I) chloride] indicate the presence of a (cyclooctadiene)(phosphoramidite)iridium chloride and of a metallocycle derived from a (cyclooctadiene)iridium bis(phosphoramidite) complex.

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Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics