HPLC of Formula: 41575-94-4. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II), is researched, Molecular C6H12N2O4Pt, CAS is 41575-94-4, about Vinblastine monotherapy induction prior to radiotherapy for patients with intracranial germinoma during the COVID-19 pandemic. Author is Murray, Matthew J.; Moleron, Rafael; Adamski, Jennifer; English, Martin; Burke, G. A. Amos; Cross, Justin; Ajithkumar, Thankamma; Stoneham, Sara; Nicholson, James C..
Patients with localized intracranial germinoma have excellent survival. Reducing treatment burden and long-term sequelae is a priority. Intensive inpatient chemotherapy (e.g., carbo PEI = carboplatin/etoposide/ifosfamide) has been effectively employed to reduce radiotherapy treatment volume/dose. Outpatient-based carboplatin monotherapy is associated with excellent outcomes in metastatic testicular seminoma (an identical pathol.), and successful vinblastine monotherapy induction (with 77% tumor volume reduction after just two weekly vinblastine doses) has recently been reported in an intracranial germinoma patient. Adapted UK guidelines for germ cell tumor management were distributed during the COVID-19 pandemic, including nonstandard treatment options to reduce hospital visits and/or admissions. This included vinblastine monotherapy for intracranial germinoma (6 mg/m2 i.v., or 4 mg/m2 for moderate count suppression, delivered weekly). We describe two such patients treated using this approach. A 30-yr-old male with a localized pineal tumor received 12-wk vinblastine induction, with >60% volume reduction, prior to definitive radiotherapy. A 12-yr-old female with a metastatic suprasellar tumor and progression at all sites of disease while awaiting proton radiotherapy received two vinblastine doses with good early response, including 36% primary tumor volume reduction The patients tolerated vinblastine well. Patients with intracranial germinoma have excellent outcomes, and reduction of late effects remains a priority. The description of vinblastine monotherapy in these intracranial germinoma patients warrants further exploration.
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