Application In Synthesis of Methyl 3-phenylpropionate. I found the field of Chemistry very interesting. Saw the article Nickel-Catalyzed Selective Reduction of Carboxylic Acids to Aldehydes published in 2019.0, Reprint Addresses Iosub, AV; Bergman, J (corresponding author), AstraZeneca, BioPharmaceut R&D, Med Chem Res & Early Dev Cardiovasc, Renal & Metab, Gothenburg, Sweden.. The CAS is 103-25-3. Through research, I have a further understanding and discovery of Methyl 3-phenylpropionate.
The direct reduction of carboxylic acids to aldehydes is a fundamental transformation in organic synthesis. The combination of an air-stable Ni precatalyst, dimethyl dicarbonate as an activator, and silane reductant effects this reduction for a wide variety of substrates, including pharmaceutically relevant structures, in good yields and with no overreduction to alcohols. Moreover, this methodology is scalable, allows access to deuterated aldehydes, and is also compatible with one-pot utilization of the aldehyde products.
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Reference:
Patent; SANOFI; US2011/294788; (2011); A1;,
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