Recommanded Product: Methyl 3-phenylpropionate. Sarver, PJ; Bacauanu, V; Schultz, DM; DiRocco, DA; Lam, YH; Sherer, EC; MacMillan, DWC in [Sarver, Patrick J.; Bacauanu, Vlad; MacMillan, David W. C.] Princeton Univ, Merck Ctr Catalysis, Princeton, NJ 08544 USA; [Schultz, Danielle M.; DiRocco, Daniel A.] Merck & Co Inc, Proc Res & Dev, Rahway, NJ 07065 USA; [Lam, Yu-hong; Sherer, Edward C.] Merck & Co Inc, Computat & Struct Chem, Rahway, NJ 07065 USA published The merger of decatungstate and copper catalysis to enable aliphatic C(sp(3))-H trifluoromethylation in 2020.0, Cited 60.0. The Name is Methyl 3-phenylpropionate. Through research, I have a further understanding and discovery of 103-25-3.
The introduction of a trifluoromethyl (CF3) group can dramatically improve a compound’s biological properties. Despite the well-established importance of trifluoromethylated compounds, general methods for the trifluoromethylation of alkyl C-H bonds remain elusive. Here we report the development of a dual-catalytic C(sp(3))-H trifluoromethylation through the merger of light-driven, decatungstate-catalysed hydrogen atom transfer and copper catalysis. This metallaphotoredox methodology enables the direct conversion of both strong aliphatic and benzylic C-H bonds into the corresponding C(sp(3))-CF3 products in a single step using a bench-stable, commercially available trifluoromethylation reagent. The reaction requires only a single equivalent of substrate and proceeds with excellent selectivity for positions distal to unprotected amines. To demonstrate the utility of this new methodology for late-stage functionalization, we have directly derivatized a broad range of approved drugs and natural products to generate valuable trifluoromethylated analogues. Preliminary mechanistic experiments reveal that a ‘Cu-CF3’ species is formed during this process and the critical C(sp(3))-CF3 bond-forming step involves the copper catalyst.
Recommanded Product: Methyl 3-phenylpropionate. Welcome to talk about 103-25-3, If you have any questions, you can contact Sarver, PJ; Bacauanu, V; Schultz, DM; DiRocco, DA; Lam, YH; Sherer, EC; MacMillan, DWC or send Email.
Reference:
Patent; SANOFI; US2011/294788; (2011); A1;,
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